185247-48-7Relevant academic research and scientific papers
3-[1,2-dicarba-closo-dodecacarboranyl-(methyleneoxy)]benzonitrile
White, Jonathan M.,Bateman, Stuart A.,Kelly, David P.,Martin, Roger F.
, p. 2785 - 2787 (1996)
The title compound, C10H17B10NO, contains a closo carbonane cage linked via a methyleneoxy tether to a substituted benzene ring. The carborane cage is essentially a regular dodecahedron with slight distortions owing to the
DNA binding compounds. VII synthesis, characterization and DNA binding capacity of 1,2-dicarba-closo-dodecaborane bibenzimidazoles related to the DNA minor groove binder Hoechst 33258
Bateman, Stuart A.,Kelly, David P.,Martin, Roger F.,White, Jonathan M.
, p. 291 - 301 (2007/10/03)
A series of bibenzimidazole derivatives based on the known DNA minor groove binder Hoechst 33258 have been prepared to include a 1,2-dicarba-closo-dodecaborane cage for potential use in boron neutron capture therapy (BNCT). The carborane derivatives (5)-(7) were chosen to reduce the steric inhibition of minor groove DNA binding displayed by the previously prepared carborane ligand (4). The synthesis and preliminary DNA binding studies of these bibenzimidazole derivatives are presented herein.
