185300-91-8

Basic information

• Product Name: Acetic acid, [(3,4-dimethoxyphenyl)methoxy]-, methyl ester
• CAS NO: 185300-91-8
• Molecular Formula: C12H16O5
• Molecular Weight: 240.256
• Mol File: 185300-91-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetic acid, [(3,4-dimethoxyphenyl)methoxy]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, [(3,4-dimethoxyphenyl)methoxy]-, methyl ester(185300-91-8)
• EPA Substance Registry System: Acetic acid, [(3,4-dimethoxyphenyl)methoxy]-, methyl ester(185300-91-8)

Safety Data

• Hazardous Substances Data: 185300-91-8(Hazardous Substances Data)

Upstream product

• 96-35-5 glycolic acid methyl ester 
• 905589-59-5 (3,4-dimethoxoxyphenyl)methyl 2,2,2-trichloroacetimidate 

Downstream Products

• 185300-92-9 (2S,5R,6S,7R)-7-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2-(3,4-dimethoxy-benzyloxy)-1-((S)-4-isopropyl-2-oxo-oxazolidin-3-yl)-6-methyl-octane-1,3-dione 
• 185300-83-8 (S)-3-[(2S,3R,5R,6S,7R)-7-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2-(3,4-dimethoxy-benzyloxy)-3-hydroxy-6-methyl-octanoyl]-4-isopropyl-oxazolidin-2-one 
• 1054698-71-3 (S)-3-[(S)-2-[(2R,4R,5S,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-5,6-dimethyl-tetrahydro-pyran-2-yl]-2-(3,4-dimethoxy-benzyloxy)-acetyl]-4-isopropyl-oxazolidin-2-one 
• 185300-85-0 (S)-3-[2-(3,4-Dimethoxy-benzyloxy)-acetyl]-4-isopropyl-oxazolidin-2-one 
• 1025909-69-6 (3,4-Dimethoxy-benzyloxy)-acetyl chloride 
• 185300-82-7 (S)-(3,4-Dimethoxy-benzyloxy)-((2R,5R,6R)-2-methoxy-5,6-dimethyl-4-methylene-tetrahydro-pyran-2-yl)-acetic acid methyl ester 
• 128271-10-3 7-(3,4-dimethoxybenzyl)pederic acid 
• 933731-96-5 (3,4-dimethoxybenzyloxy) acetic acid 

Relevant articles and documents

Highly diastereoselective synthesis of pederic acid derivatives

A highly diastereoselective synthesis of methyl pederate (2) is described. A critical feature of the successful route is the introduction of the key C(7)-stereocenter at the stage of 4 via an enantioselective, syn-selective aldol reaction of aldehyde 5 and the chiral acyl oxazolidinone 6. Aldehyde 5, in turn, was prepared from the readily available aldol derivative 7 via a chelate-controlled reaction with allyltrimethylsilane. Intermediate 4 was elaborated to 2 via the intermediacy of 7-O-(3,4-dimethoxybenzyl)pederic acid (3), an intermediate in Kishi's syntheses of mycalamides A and B and onnamide A, by way of methyl pyranoside 16 and the fully protected pederic acid derivative 11.