185302-70-9

Upstream product

• 824-42-0 2-methoxy-3-methylbenzaldehyde 
• 95-48-7 ortho-cresol 
• 288-32-4 1H-imidazole 
• 22470-99-1 3-methylsalicyl alcohol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1433061-94-9 (2R)-ethyl 2-(2’-bromomethyl-6’-methylphenoxy)propanoate 
• 1433061-64-3 C₁₃H₁₈O₄ 
• 1433061-34-7 C₁₉H₃₂O₄Si 
• 224648-41-3 ethyl 2-tert-butyl-dimethylsilyloxymethyl-6-methyl-phenoxyacetate 

Relevant academic research and scientific papers

Asymmetric induction via short-lived chiral enolates with a chiral C-O axis

A novel method has been developed for the asymmetric cyclization of alkyl aryl ethers. The reactions were assumed to proceed via short-lived chiral enolate intermediates with a chiral C-O axis to give cyclic ethers with tetrasubstituted carbon in up to 99% ee. The half-life of racemization of the chiral enolate intermediate was roughly estimated to be ～1 s at -78 C.

RETROVIRAL PROTEASE INHIBITING COMPOUNDS

A compound of the formula: STR1 is disclosed as a retroviral protease inhibitor compound. Also disclosed are methods and compositions for inhibiting an HIV infection.

Chiral synthesis of (+)-8′-demethyl abscisic acid

An enantioselective synthesis of (+)-8′-demethyl ABA (2) is described. The chiral intermediate 7 was prepared by yeast reduction of a substituted monoprotected cyclohexa-2,5-dien-1,4-dione (9) synthesized through a phenol oxidation. The scope and limitations of the phenol oxidation is described. 8′-Demethyl ABA shows ABA-like activity in wheat embryo germination inhibition, showing that the 8′-methyl group is not essential for biological activity.