185342-88-5Relevant articles and documents
Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors
Robke, Lucas,Rodrigues, Tiago,Schr?der, Peter,Foley, Daniel J.,Bernardes, Gon?alo J.L.,Laraia, Luca,Waldmann, Herbert
supporting information, p. 4531 - 4537 (2018/07/30)
Autophagy is a catabolic process, which mediates degradation of cellular components and has important roles in health and disease. Therefore, small molecule modulators of autophagy are in great demand. Herein, we describe a phenotypic high-content screen for autophagy inhibitors, which led to the discovery of a dimethoxypyridine-based class of autophagy inhibitors, which derive from previously reported, natural product-inspired MAP4K4 inhibitors. Comprehensive structure-activity relationship studies led to a potent compound, and biological validation experiments indicated that the mode of action was upstream or independent of mTOR.
COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
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, (2017/03/21)
When a decrease in low-grey level region (e.g., 0 to 80 grey) efficiencies of organic light emitting devices is not constant, deviation among display panels may cause color change and stain in the low luminance region. Aspects of the present disclosure ar
ANTHRACENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT USING THE SAME
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, (2012/04/17)
An anthracene derivative represented by the following formula (1): In the formula (1), Z is a structure represented by the following formula (2). In the formula (2), at least one pair of adjacent two substituents of R11 to R18 form a ring represented by the following formula (3) or (4):