185382-06-3

Upstream product

• 152120-54-2 N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine 
• 130525-62-1 5-acetamido-4-amino-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid 
• 908093-98-1 diazodiphenylmethane 

Downstream Products

• 185382-08-5 (2R,3R,4S)-3-(acetylamino)-4-(2,3-bis(tert-butoxycarbonyl)guanidino)-3,4-dihydro-2H-pyran-2,6-dicarboxylic acid 6-benzhydryl ester 2-(2,3,4,5,6-pentafluorophenyl) ester 
• 1053704-50-9 C₄₅H₆₅N₅O₉ 
• 185382-10-9 (4S,5R,6R)-5-(acetylamino)-4-(2,3-bis(tert-butoxycarbonyl)guanidino)-6-(dipropylcarbamoyl)-5,6-dihydro-4H-pyran-2-carboxylic acid benzhydryl ester 
• 1053268-19-1 C₃₇H₄₉N₅O₉ 
• 185382-04-1 (2R,3R,4S)-3-(acetylamino)-4-(2,3-bis(tert-butoxycarbonyl)guanidino)-3,4-dihydro-2H-pyran-2,6-dicarboxylic acid 6-benzhydryl ester 

Relevant academic research and scientific papers

Dihydropyrancarboxamides related to zanamivir: A new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4h-pyran-6-carboxamides

4-Amino- and 4-guanidino-4ff-pyran-6-carboxamides 4 and 5 related to zanamivir (GG167) are a new class of inhibitors of influenza virus sialidases. Structure-activity studies reveal that, in general, secondary amides are weak inhibitors of both influenza