185397-10-8Relevant academic research and scientific papers
Regio- and enantioselective synthesis of allenic esters by samarium(II)-mediated reduction of propargylic compounds through dynamic kinetic protonation
Mikami, Koichi,Yoshida, Akihiro
, p. 889 - 898 (2001)
Regioselective synthesis of allenic esters was attained by SmI2-mediated reduction of propargylic phosphates and ethers bearing alkoxycarbonyl groups at the acetylene terminus. Using suitable chiral proton source in this system, highly enantio-
Catalytic asymmetric carbonyl-ene reactions with alkynylogous and vinylogous glyoxylates: Application to controlled synthesis of chiral isocarbacyclin analogues
Mikami, Koichi,Yoshida, Akihiro,Matsumoto, Youichi
, p. 8515 - 8518 (2007/10/03)
The asymmetric carbonyl-ene reaction with alkynylogous and vinylogous glyoxylates (1, 2) catalyzed by a binaphthol-derived chiral titanium complex is described. The catalytic asymmetric ene reaction with aldehyde (1) can be applied to the double asymmetric synthesis of isocarbacyclin analogues bearing a 2-allenyl side chain.
