185399-89-7Relevant academic research and scientific papers
Synthesis of an esperamicin core analog with an epoxide trigger
Mastalerz, Harold,Doyle, Terrence W.,Kadow, John F.,Vyas, Dolatrai M.
, p. 8683 - 8686 (2007/10/03)
An esperamicin core analog 4 with an epoxide trigger like that found in the related enediyne, dynemicin, was prepared. Surprisingly, it was found to be relatively stable; the p-aminophenyl substituent did not facilitate epoxide solvolysis to the extent that had been anticipated. A mild acid, pyridinium p-toluenesulfonate, was found to induce solvolysis of 4 and led to the formation of the cycloaromatized product 25.
