1854-53-1Relevant academic research and scientific papers
Stereochemical Applications of Mass Spectrometry
Harrison, Alex G.,Kallury, R. K. M. R.
, p. 249 - 256 (1980)
A study of the electron impact and chemical ionization (H2, CH4 and iso-C4H10) mass spectra stereoisomeric benzoin oximes and phenylhydrazones indicates that while the former can be distinguished only by their chenical ionization mass spectra the latter a
Zinc salt-catalyzed reduction of α-aryl imino esters, diketones and phenylacetylenes with water as hydrogen source
Shen, Guoli,Liu, Haojie,Chen, Jingchao,He, Zhenxiu,Zhou, Yongyun,Wang, Lin,Luo, Yang,Su, Zhimin,Fan, Baomin
supporting information, p. 3601 - 3610 (2021/05/04)
The zinc salt-catalyzed reduction of α-aryl imino esters, diketones and phenylacetylenes with water as hydrogen source and zinc as reductant was successfully conducted. The presented method provides a low-cost, environmentally friendly and practical preparation of α-aryl amino esters, α-hydroxyketones and phenylethylenes. By using D2O as deuterium source, the corresponding products were obtained in high efficiency with excellent deuterium incorporation rate, which gives a cheap and safe tool for access to valuable deuterium-labelled compounds. This journal is
Photocatalytic Coproduction of Deoxybenzoin and H2 through Tandem Redox Reactions
Luo, Nengchao,Hou, Tingting,Liu, Shiyang,Zeng, Bin,Lu, Jianmin,Zhang, Jian,Li, Hongji,Wang, Feng
, p. 762 - 769 (2020/01/02)
Photocatalytic H2 evolution from organic feedstocks with simultaneous utilization of photogenerated holes achieves solar energy storage and coproduces value-Added chemicals. Here we show visible-light H2 production from benzyl alcohol (BAL) with controllable generation of deoxybenzoin (DOB) or benzoin (BZ) through tandem redox reactions. Particularly, DOB synthesis circumvents the use of expensive feedstocks and environmentally unfriendly catalysts that are required previously. Under the irradiation of blue LEDs, the key of steering the major product to DOB rather than BZ is to decrease the conduction band bottom potentials of the ZnIn sulfide catalysts by increasing the Zn/In ratio, which results in the dehydration of intermediate hydrobenzoin (HB) to DOB proceeding in a redox-neutral mechanism and consuming an electron-hole pair. As a proof of concept, this method is used to synthesize DOB derivatives in gram scale.
Method for preparing deuterated benzoin by taking heavy water as deuterium source
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Paragraph 0033-0036, (2020/09/16)
The invention discloses a method for preparing deuterated benzoin by taking heavy water as a deuterium source, wherein a benzil compound and heavy water are used as reaction raw materials, a lewis acid is used as a catalyst, and a reaction is performed in
Practical Method for Reductive Deuteration of Ketones with Magnesium and D2O
Bao, Hongli,Li, Yajun,Su, Min,Wan, Wen-Ming,Zhu, Nengbo
supporting information, (2020/02/15)
α-Deuterated alcohols have important applications in pharmaceuticals and mechanism studies. Here, we report a new and practical strategy for the reductive deuteration of ketones using a Mg/BrCH2CH2Br/D2O system, which affords α-deuterated alcohols in good yields and with almost quantitative incorporation of deuterium. The synthetic value of this method has been demonstrated by the easy access to deuterated drugs or drug derivatives. This method may inspire the discovery of other deuterium-containing drugs.
