185407-03-8

Upstream product

• 2973-58-2 2-bromoisovanillin 
• 1521-51-3 rac-3-bromocyclohexene 
• 822-67-3 Cyclohex-2-enol 
• 1972-28-7 diethylazodicarboxylate 

Downstream Products

• 157397-94-9 2-Bromo-3-(cyclohex-2-enyloxy)-4-methoxy-1-((E)-2-phenylsulfanyl-vinyl)-benzene 
• 157397-87-0 (Z)-3-[2-Bromo-3-(cyclohex-2-enyloxy)-4-methoxy-phenyl]-acrylonitrile 
• 157397-86-9 (E)-3-[2-Bromo-3-(cyclohex-2-enyloxy)-4-methoxy-phenyl]-acrylonitrile 
• 157397-82-5 (E)-3-[2-Bromo-3-(cyclohex-2-enyloxy)-4-methoxy-phenyl]-acrylic acid methyl ester 
• 157397-88-1 2-Bromo-3-(cyclohex-2-enyloxy)-4-methoxy-1-vinyl-benzene 
• 157397-83-6 {(E)-2-[2-Bromo-3-(cyclohex-2-enyloxy)-4-methoxy-phenyl]-vinyl}-carbamic acid ethyl ester 
• 157397-89-2 (E)-3-[2-Bromo-3-(cyclohex-2-enyloxy)-4-methoxy-phenyl]-acrylic acid 

Relevant academic research and scientific papers

Derivatives of benzofuran or benzodioxole

An oxygen-containing heterocyclic compound represented by following Formula (I): wherein R1and R2independently represent hydrogen, lower alkyl, cyano, —(CH2)n—E1—CO—G1(wherein E1represents a bond, O, or NH; and G1represents hydrogen, substituted or unsubstituted lower alkyl, OR6, or NR7R8; and n represents an integer of 0 to 4), or the like; R1and R2are combined to represent a saturated carbon ring together with a carbon atom adjacent thereto; or R2, and R11or R13described below are combined to form a single bond; R3represents hydrogen, phenyl, or halogen; R4represents hydroxy, lower alkoxy, or the like; A represents —C(R9)(R10)— or O; B represents O, NR11, —C(R12)(R13)—, or —C(R14)(R15)—C(R16)(R17)—; D represents (i) —C(R18)(R19)—X— (wherein X represents —C(R21)(R22)—, S, or NR23), (ii) —C(R19a)═Y— [Y represents —C(R24)—Z— (wherein Z represents CONH, CONHCH2, or a bond), or N], or (iii) a bond; and R5represents aryl, an aromatic heterocyclic group, cycloalkyl, pyridine-N-oxide, cyano, or lower alkoxycarbonyl; or pharmaceutically acceptable salts thereof.

DERIVATIVES OF BENZOFURAN OR BENZODIOXOLE

An oxygen-containing heterocyclic compound represented by following Formula (I): wherein R1 and R2 independently represent hydrogen, lower alkyl, cyano, —(CH2)n—E1—CO—G1 (wherein E1 represents a bond, O, or NH; and G1 represents hydrogen, substituted or unsubstituted lower alkyl, OR6, or NR7R8; and n represents an integer of 0 to 4), or the like; R1 and R2 are combined to represent a saturated carbon ring together with a carbon atom adjacent thereto; or R2, and R11 or R13 described below are combined to form a single bond; R3 represents hydrogen, phenyl, or halogen; R4 represents hydroxy, lower alkoxy, or the like; A represents —C(R9)(R10)— or O; B represents O, NR11, —C(R12)(R13)—, or —C(R14)(R15)—C(R16)(R17)—; D represents (i) —C(R18)(R19)—X— (wherein X represents —C(R21)(R22)—, S, or NR23), (ii) —C(R19a)═Y— [Y represents —C(R24)—Z— (wherein Z represents CONH, CONHCH2, or a bond), or N], or (iii) a bond; and R5 represents aryl, an aromatic heterocyclic group, cycloalkyl, pyridine-N-oxide, cyano, or lower alkoxycarbonyl; or pharmaceutically acceptable salts thereof.

Stereochemistry of radical cyclizations to side-chain olefinic bonds. An approach to control of the C-9 center of morphine

Styrenes of general structure 5 undergo tandem radical cyclization to cis,cis-hydrophenanthrofurans 9, products which contain the carbocyclic skeleton of the morphine alkaloids. Vinylurethane 5E-NHCO2Et cyclizes to 9α via the intermediate radic