185420-99-9

Upstream product

• 129101-19-5 (all-R)-2-Azabicyclo[3.3.0]octan-3-oic acid benzyl ester p-toluenesulfonate 
• 185420-77-3 1-tert-butyl-2,8-dioxabicyclo-[3.3.1]nonane-3,7-dione 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 185420-79-5 2-(2-Methoxycarbonyl-1-methoxycarbonylmethyl-ethyl)-4,4-dimethyl-3-oxo-pentanoic acid methyl ester 
• 5164-76-1 dimethyl glutaconate 
• 55107-14-7 Methyl 4,4-dimethyl-3-oxopentanoate 

Relevant academic research and scientific papers

Chemical differentiation of enantiotopic groups: Diastereoselective opening of a prochiral dilactone

Prochiral dilactone 1 has been synthesized and subjected to diastereoselective nucleophilic opening. The structural features of chiral, enantiomerically pure nucleophiles have been optimized regarding their capability to perform prochiral recognition at dilactone 1. 3-Ketoglutaric mono acid products 2 of dilactone opening, which are versatile building blocks for natural product synthesis, have been obtained in diastereomeric ratios up to 84:16 and were enriched by subsequent crystallization to 97.5:2.5.