185428-88-0

Basic information

• Product Name: 5-(4-methoxycarbonylmethyloxybenzyl)thiazolidine-2,4-dione
• Synonyms: 5-(4-methoxycarbonylmethyloxybenzyl)thiazolidine-2,4-dione
• CAS NO: 185428-88-0
• Molecular Weight: 295.316
• Mol File: 185428-88-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(4-methoxycarbonylmethyloxybenzyl)thiazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-methoxycarbonylmethyloxybenzyl)thiazolidine-2,4-dione(185428-88-0)
• EPA Substance Registry System: 5-(4-methoxycarbonylmethyloxybenzyl)thiazolidine-2,4-dione(185428-88-0)

Safety Data

• Hazardous Substances Data: 185428-88-0(Hazardous Substances Data)

Downstream Products

• 185428-23-3 5-[4-(5-hydroxy-1,4,6,7-tetramethyl-1H-benzimidazol-2-ylmethoxy)benzyl]thiazolidine-2,4-dione 
• 185428-18-6 rivoglitazone 

Relevant articles and documents

Benzimidazole derivatives, their preparation and their therapeutic use

Compounds of formula (I): STR1 [wherein: X represents an optionally substituted benzimidazole group; Y represents an oxygen or sulfur atom; Z represents a 2,4-dioxothiazolidin-5-ylidenylmethyl, 2,4-dioxothiazolidin-5-ylmethyl, 2,4-dioxooxazolidin-5-ylmethyl, 3,5-dioxooxadiazolidin-2-ylmethyl or N-hydroxyureidomethlyl group; R represents hydrogen, alkyl, alkoxy, halogen, hydroxy, nitro, amino or aralkyl; and m is an integer from 1 to 5]; have valuable activity for the treatment and/or prophylaxis of a variety of disorders, including one or more of: hyperlipemia, hyperglycemia, obesity, impaired glucose tolerance (IGT), insulin resistance and diabetic complications.

Benzimidazole derivatives, their preparation and their therapeutic use

Compounds of formula (I): [in which: X represents an optionally substituted benzimidazole group; Y represents an oxygen or sulphur atom; Z represents a 2,4-dioxothiazolidin-5-ylidenylmethyl, 2,4-dioxothiazolidin-5-ylmethyl, 2,4-dioxo-oxazolidin-5-ylmethyl, 3,5-dioxooxadiazolidin-2-ylmethyl or N-hydroxyureidomethyl group; R represents hydrogen, alkyl, alkoxy, halogen, hydroxy, nitro, amino or aralkyl; and mis an integer from 1 to 5]; have valuable activity for the treatment and/or prophylaxis of a variety of disorders, including one or more of: hyperlipemia, hyperglycemia, obesity, impaired glucose tolerance (IGT), insulin resistance and diabetic complications.