185430-32-4 Usage
Furanone ring
The compound contains a furanone ring, which is a five-membered heterocyclic ring with an oxygen atom and a carbonyl group (C=O).
Hydroxy group
The compound has a hydroxy group (-OH) attached to the furanone ring, which can form hydrogen bonds and participate in various chemical reactions.
Hexadecyl chain
The compound has a long hexadecyl chain (a 16-carbon alkyl chain) with a carbonyl group (C=O) at one end, which can provide hydrophobic and lipophilic properties.
Triphenylmethoxy methyl group
The compound contains a triphenylmethoxy methyl group (a methyl group attached to a triphenylmethoxy group), which can provide steric hindrance and influence the compound's reactivity and physical properties.
Chiral molecule
The compound is a chiral molecule, meaning it has a specific three-dimensional arrangement of atoms and can exist in different enantiomeric forms.
(5R) designation
The compound has a specific stereochemistry, denoted by the (5R) designation, which indicates the configuration of the carbon atom at position 5 in the furanone ring.
Potential applications
The compound has potential applications in various fields, including pharmaceuticals, materials science, and organic chemistry research, but further investigation and synthesis are needed to determine its specific properties and uses.
Check Digit Verification of cas no
The CAS Registry Mumber 185430-32-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,4,3 and 0 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 185430-32:
(8*1)+(7*8)+(6*5)+(5*4)+(4*3)+(3*0)+(2*3)+(1*2)=134
134 % 10 = 4
So 185430-32-4 is a valid CAS Registry Number.
185430-32-4Relevant academic research and scientific papers
Solution-phase and solid-phase syntheses of enzyme inhibitor RK-682 and antibiotic agglomerins
Schobert, Rainer,Jagusch, Garsten
, p. 6129 - 6132 (2007/10/03)
The enzyme inhibitor RK-682 (5A)-(+)-1 was prepared in solution and on a solid support from (2R)-glycerates in five steps and ca. 40% overall yield. Key steps were a ring-closing tandem addition-Wittig alkenation reaction of the respective protected or im
Asymmetric synthesis of a 3-acyltetronic acid derivative, RK-682, and formation of its calcium salt during silica gel column chromatography
Sodeoka,Sampe,Kojima,Baba,Morisaki,Hashimoto
, p. 206 - 212 (2007/10/03)
RK-682 was reported to be a potent protein tyrosine phosphatase inhibitor. We found that (R)-3-hexadecanoyl-5-hydroxymethyltetronic acid (I) was easily converted to its calcium salt during column chromatography on Silica gel 60, and this calcium salt was identical to RK-682 originally isolated from a natural source. Here we report details of the asymmetric synthesis of (R)-I and its conversion to the calcium salt. Fast atom bombardment mass spectrometric (FAB-MS) analysis of the free and calcium salt forms of RK-682 is also reported.
Asymmetric synthesis of RK-682 and its analogs, and evaluation of their protein phosphatase inhibitory activities
Sodeoka, Mikiko,Sampe, Ruriko,Kagamizono, Terumi,Osada, Hiroyuki
, p. 8775 - 8778 (2007/10/03)
We report an asymmetric synthesis of a potent tyrosine phosphatase inhibitor, RK-682 and its analogs. The absolute stereochemistry of RK-682 was determined to be (R). The inhibitory activities of RK-682 and its analogs, (R)-1a, (S)-1a, (R)-1b and (R)-1c toward various protein phosphatases (VHR, cdc25A, cdc25B, and PPI) are also reported.
