185450-04-8Relevant articles and documents
Cyclic HIV-1 protease inhibitors derived from mannitol: Synthesis, inhibitory potencies, and computational predictions of binding affinities
Hultén, Johan,Bonham, Nicholas M.,Nillroth, Ulrika,Hansson, Tomas,Zuccarello, Guido,Bouzide, Abderrahim,?qvist, Johan,Classon, Bj?rn,Danielson, U. Helena,Karlén, Anders,Kvarnstr?m, Ingemar,Samuelsson, Bertil,Hallberg, Anders
, p. 885 - 897 (1997)
Ten C2-symmetric cyclic urea and sulfamide derivatives have been synthesized from L-mannonic γ-lactone and D-mannitol. The results of experimental measurement of their inhibitory potencies against HIV-1 protease were compared to calculated free