185461-59-0

Upstream product

• 185461-58-9 (2RS,4S)-N-(4-Benzyloxy-2,5-dimethyl-3-oxohexanoyl)leucine trichloroethyl ester 

Downstream Products

• 185461-50-1 cyclo-[N(Me)-O(Me)-Tyr-O-[Boc-(R)-N(Me)-Leu->-Thr-Ist(TBDMS)-Hip-Leu-Pro-> 
• 137219-37-5 dehydrodidemnin B 
• 185461-54-5 Boc-(R)-N(Me)-Leu-Thr[Z-N(Me)-O(Me)-Tyr]-Ist(TBDMS)-Hip-Leu-Pro-OH 
• 185461-53-4 Boc-(R)-N(Me)-Leu-Thr[Z-N(Me)-O(Me)-Tyr]-Ist(TBDMS)-Hip-Leu-Pro-OTce 
• 185461-55-6 Boc-(R)-N(Me)-Leu-Thr[H-N(Me)-O(Me)-Tyr]-Ist(TBDMS)-Hip-Leu-Pro-OH 
• 185461-60-3 (S)-1-[(S)-2-((S)-4-Benzyloxy-2,5-dimethyl-3-oxo-hexanoylamino)-4-methyl-pentanoyl]-pyrrolidine-2-carboxylic acid 2,2,2-trichloro-ethyl ester 

Relevant academic research and scientific papers

Total synthesis of dehydrodidemnin B. Use of uronium and phosphonium salt coupling reagents in peptide synthesis in solution

New total syntheses of didemnin A and of dehydrodidemnin B are described. The latter didemnin has the highest antiproliferative activity of all members of this family of macrocyclic depsipeptides. It was produced on coupling the side chain Pyr-Pro-OH to d