1855-28-3

Usage

General Description

2-(2,6-Diisopropylphenyl)acetic acid is a chemical compound with the molecular formula C14H20O2. It is a derivative of acetic acid and belongs to the class of phenylacetic acids. 2-(2,6-Diisopropylphenyl)acetic acid is commonly used in the pharmaceutical industry as a precursor in the synthesis of various drugs, particularly non-steroidal anti-inflammatory drugs (NSAIDs) and other pharmaceuticals. It has also been studied for its potential anti-inflammatory and analgesic properties. Additionally, it has been used in the synthesis of chiral ligands for asymmetric catalysis. The presence of isopropyl groups in its structure contributes to its unique properties and applications.

Upstream product

• 57190-17-7 2-bromo-1,3-diisopropylbenzene 
• 156023-24-4 2-ethenyl-1,3-bis(propan-2-yl)benzene 
• 2225-13-0 ethyl 2-(2,6-diisopropylphenyl)acetate 

Relevant academic research and scientific papers

NLRP3 MODULATORS

Described herein are NLRP3 modulators and methods of utilizing NLRP3 modulators in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.

SULFONAMIDE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of Formula (I) or (II): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

In one aspect, compounds of Formula A, or a pharmaceutically acceptable salt thereof, are featured (Formula A) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.

Phosphonamide ACAT inhibitors

The present invention is directed to compounds useful for the regulation of cholesterol of Formula I, methods for using them and pharmaceutical compositions thereof, STR1 wherein Ar and Ar1 are each independently selected from unsubstituted or substituted phenyl which substituents are from 1-5 in number and are each independently selected from alkyl, alkoxy, hydroxy, halogen, nitro, trifluoromethyl, COOH, and COOalkyl; X is --NH--, --O--, --S--, or --(CH2)0-4 --, and R is hydrogen, alkyl, or phenyl.