1855-40-9

Usage

Uses

Used in Pharmaceutical Industry:
3-CHLOROPHENYL CYCLOPENTYL KETONE is used as a synthetic intermediate for the development of [ketamine-related compounds] for [potential anesthetic properties]. Its role in creating new anesthetic agents is vital, as it can lead to the discovery of more effective and safer options for medical procedures requiring anesthesia.
Used in Anesthetic Research:
3-CHLOROPHENYL CYCLOPENTYL KETONE is used as a research compound for [exploring the anesthetic properties of ketamine-related compounds]. This application aids in understanding the mechanisms of action and potential side effects of these compounds, ultimately contributing to the advancement of anesthetic science and the improvement of patient care during medical and surgical procedures.

InChI:InChI=1/C12H13ClO/c13-11-7-3-6-10(8-11)12(14)9-4-1-2-5-9/h3,6-9H,1-2,4-5H2

Upstream product

• 287-92-3 Cyclopentane 
• 201230-82-2 carbon monoxide 
• 4405-42-9 m-chlorophenyltrimethylsilane 
• 587-04-2 m-Chlorobenzaldehyde 
• 766-84-7 3-chloro-benzonitrile 
• 33240-34-5 cyclopentylmagnesium bromide 

Downstream Products

• 52123-79-2 <α-Brom-cyclopentyl>-<3-chlor-phenyl>-keton 

Relevant academic research and scientific papers

Catalytic Asymmetric Acyloin Rearrangements of α-Ketols, α-Hydroxy Aldehydes, and α-Iminols by N, N′-Dioxide-Metal Complexes

A highly enantioselective acyloin rearrangement of cyclic α-ketols has been developed with a chiral Al(III)-N,N′-dioxide complex as catalyst. This strategy provided an array of optically active 2-acyl-2-hydroxy cyclohexanones in moderate to good yields with high enantioselectivities. The asymmetric isomerizations of acyclic α-hydroxy aldehydes and α-iminols were achieved as well under modified conditions, affording the corresponding chiral α-hydroxy ketones and α-amino ketones in moderate results. Moreover, further transformations of product to enantioenriched diols were carried out.

Synthesis of Ketones through Microwave Irradiation Promoted Metal-Free Alkylation of Aldehydes by Activation of C(sp3)-H Bond

In this paper, a novel methodology for the synthesis of ketones via microwave irradiation promoted direct alkylation of aldehydes by activation of the inert C(sp3)-H bond has been developed. Notably, the reactions were accomplished under metal-free conditions and used commercially available aldehydes and cycloalkanes as substrates without prefunctionalization. By using this novel method, an alternative synthetic approach toward the key intermediates for the preparation of the pharmaceutically valuable oxaspiroketone derivatives was successfully established.

Direct catalytic asymmetric three-component Kabachnik-fields reaction

(Chemical Equation Presented) As mimics of α-amino acids, α-amino phosphonates have great promise as antibacterial and anti-HIV agents as well as protease inhibitors. Racemic α-branched aldehydes react, in the presence the new chiral phosphoric acid catalyst 1, directly with p-anisidine (PMPNH2) and a phosphite to furnish β-branched α-amino phosphonates highly diastereoselectively and enantioselectively. Anth = anthracenyl.

A new efficient and selective synthesis of ketones from alkanes or cycloalkanes, CO, and silanes in the presence of aprotic superacids

A new approach to the direct synthesis of ketones from alkanes or cycloalkanes (RH), CO, and silanes is proposed. Ketones were obtained in 50-97% yields from propane, butane, cyclopentane, cyclohexane, and methylcyclopentane on treatment with CO and silanes (Me4Si, Et4Si, or m-and p-XC6H4SiMe3, where X = Cl, Me, OMe) in the presence of CX4 · 2AlBr3 (X = Br, Cl) superacids at 0 °C. The reactions with m-and p-XC6H4SiMe3 (X = Cl, Me) occur regioselectively to give m-ketones from m-silanes and p-ketones from p-silanes. However, the only product, p-MeOC6H4COR, is formed both from m-and p-MeOC6H4SiMe3. The reaction of Cyclo-C5H9CO+ with BzSiMe3 results in an organosilicon ketone, Me3SiCH2QH4COC5H9, while in the presence of an excess of an acylating system (after alcoholysis), Me2Si(OR′)CH2C6H4COR is formed.