185501-77-3 Usage
Uses
Used in Pharmaceutical Applications:
Phosphonic acid, [3-[[3-(2-amino-2-oxoethyl)-2-ethyl-6-(1-methylethyl)-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-, dimethyl ester is used as a potential pharmaceutical agent for its unique structure and properties. It may be employed in the development of new drugs or as a key intermediate in the synthesis of complex molecules.
Used in Organic Synthesis:
In the field of organic synthesis, Phosphonic acid, [3-[[3-(2-amino-2-oxoethyl)-2-ethyl-6-(1-methylethyl)-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-, dimethyl ester serves as a valuable building block for the creation of more complex molecules. Its unique structure allows for various chemical reactions and modifications, making it a versatile component in the synthesis of novel compounds.
Used in Materials Science:
Phosphonic acid, [3-[[3-(2-amino-2-oxoethyl)-2-ethyl-6-(1-methylethyl)-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-, dimethyl ester may also find applications in materials science, where its unique properties could be harnessed to develop new materials with specific characteristics. Further research is needed to explore its potential in this field and to understand its limitations.
Check Digit Verification of cas no
The CAS Registry Mumber 185501-77-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,5,0 and 1 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 185501-77:
(8*1)+(7*8)+(6*5)+(5*5)+(4*0)+(3*1)+(2*7)+(1*7)=143
143 % 10 = 3
So 185501-77-3 is a valid CAS Registry Number.
185501-77-3Relevant academic research and scientific papers
Indole inhibitors of human nonpancreatic secretory phospholipase A2. 2. Indole-3-acetamides with additional functionality
Dillard, Robert D.,Bach, Nicholas J.,Draheim, Susan E.,Berry, Dennis R.,Carlson, Donald G.,Chirgadze, Nickolay Y.,Clawson, David K.,Hartley, Lawrence W.,Johnson, Lea M.,Jones, Noel D.,McKinney, Emma R.,Mihelich, Edward D.,Olkowski, Jennifer L.,Schevitz, Richard W.,Smith, Amy C.,Snyder, David W.,Sommers, Cynthia D.,Wery, Jean-Pierre
, p. 5137 - 5158 (2007/10/03)
As reported in our previous paper, a series of indole-3-acetamides which possessed potency and selectivity as inhibitors of human nonpancreatic secretory phospholipase A2(hnps-PLA2) was developed. The design of these compounds was based on information derived from x-ray crystal structures determined for complexes between the enzyme and its inhibitors. We describe here the further implementation of this structure-based design strategy and continued SAR development to produce indole-3-acetamides with additional functionalities which provide increased interaction with important residues within the enzyme active site. These efforts led to inhibitors with substantially enhanced potency and selectivity.
