185520-18-7Relevant articles and documents
Distorted Gold(I)-Phosphine Complexes as Antifungal Agents
Dennis, Emily K.,Kim, Jong Hyun,Parkin, Sean,Awuah, Samuel G.,Garneau-Tsodikova, Sylvie
, p. 2455 - 2469 (2020)
Fungi cause serious nosocomial infections including candidiasis and aspergillosis, some of which display reduced susceptibility to current antifungals. Inorganic compounds have been found to be beneficial against various medical ailments but have yet to be applied to fungal infections. Here, we explore the activity of linear and square-planar gold(I)-phosphine complexes against a panel of 28 fungal strains including Candida spp., Cryptococcus spp., Aspergillus spp., and Fusarium spp. Notably, two square-planar gold(I) complexes with excellent broad-spectrum activity display potent antifungal effects against strains of Candida auris, an emerging multidrug-resistant fungus that presents a serious global health threat. To characterize the biological activity of these gold(I) complexes, we used a series of time-kill studies, cytotoxicity and hemolysis assays, as well as whole-cell uptake and development of resistance studies.
Exploiting aurophilic interactions in a [2 + 2] photocycloaddition: Single-crystal reactivity with changes to surface morphology
Li, Changan,Campillo-Alvarado, Gonzalo,Swenson, Dale C.,Macgillivray, Leonard R.
, p. 12497 - 12500 (2019)
A single-crystal-to-single-crystal (SCSC) photodimerization is achieved using Au(I) coordination and aurophilic interactions. The rigid Au2(dppbz)(CF3COO)2 precursor (dppbz = 1,2-bis(diphenylphosphino)benzene) self-assembles with 1,2-trans-bis(4-pyridyl)ethylene (bpe) to afford a discrete [Au4(dppbz)2(bpe)2]4+ macrocycle in the solid state. The alkene undergoes a [2 + 2] photocycloaddition reaction. The photoreaction proceeds via a rare SCSC transformation in quantitative yield that generates [Au4(dppbz)2(4,4′-tpcb)]4+ (4,4′-tpcb = rctt-tetrakis(4-pyridyl)cyclobutane) stereoselectively. Mechanical strain induced by the photoreaction is evidenced by the formation of ramp features on single-crystal surfaces using scanning electron microscopy.
