185536-75-8Relevant academic research and scientific papers
The Acrylamide Moiety as an Activated Alkene Component in the Intramolecular Baylis-Hillman Reaction: Facile Synthesis of Functionalized α-Methylene Lactam and Spirolactam Frameworks
Basavaiah, Deevi,Reddy, Guddeti Chandrashekar,Bharadwaj, Kishor Chandra
, p. 1157 - 1162 (2014)
A facile strategy for the intramolecular Baylis-Hillman reaction by utilizing an acrylamide moiety as an activated alkene component was developed, which thus provides a convenient protocol for obtaining five- and six-membered α-methylene lactam and spirolactam derivatives.
The acrylamide moiety as an activated alkene component in the intramolecular Baylis-Hillman reaction: Facile synthesis of functionalized α-methylene lactam and spirolactam frameworks
Basavaiah, Deevi,Reddy, Guddeti Chandrashekar,Bharadwaj, Kishor Chandra
, p. 1157 - 1162 (2014/03/21)
A facile strategy for the intramolecular Baylis-Hillman reaction by utilizing an acrylamide moiety as an activated alkene component was developed, which thus provides a convenient protocol for obtaining five-and six-membered α-methylene lactam and spirolactam derivatives. An intramolecular Baylis-Hillman reaction by using an acrylamide moiety as an activated alkene and an aldehyde as the electrophile component is described. Thus, a simple synthetic strategy for obtaining α-methylene (γ-and δ-)lactam and spiro-γ-lactam derivatives is provided. DABCO = 1,4-diazabicyclo[2.2. 2]octane. Copyright
