185672-33-7Relevant academic research and scientific papers
Improvement of the synthesis of vitamin E catalyzed by montmorillonite
Duan, Hui-Yun,Wang, Zhen-Hua,Li, Ji-Tai,Li, Sheng-Hui,Li, Li-Jun,Li, Tong-Shuang
, p. 1867 - 1872 (2003)
Montmorillonite K 10 or montmorillonite K 10-supported metal salt as catalysts to synthesize VE (yield 21.0-64.4%) with 2,3,5-trimethylhydroquinone and isophytol. The catalysts can be reused.
Synthesis of α-tocopherol: Scandium(III) trifluoromethanesulfonate as an efficient catalyst in the reaction of hydroquinone with allylic alcohol
Matsui,Karibe,Hayashi,Yamamoto
, p. 3569 - 3571 (1995)
Scandium(III) trifluoromethanesulfonate was found to be an efficient catalyst as a Lewis acid for the condensation reaction of trimethylhydroquinone with isophytol to afford α-tocopherol. The condensation reaction proceeded smoothly using only a 0.001 molar amount of the catalyst. The catalyst was easily recovered from an aqeous layer after the reaction was completed, and could be reused.
Synthesis of D,L-α-tocopherol using strong solid acids as catalysts
Schager, Frank,Bonrath, Werner
, p. 282 - 284 (1999)
The synthesis of D,L-α-tocopherol starting from trimethylhydroquinone and isophytol using a heterogeneous solid acid catalyst, e.g., Nafion NR 50, is described. Advantages of this new procedure are high yield and selectivity, facile recovery of the catalyst, no waste problems, and mild reaction conditions.
Synthesis of (all-rac)-α-tocopherol in supercritical carbon dioxide: Tuning of the product selectivity in batch and continuous-flow reactors
Kokubo, Yoshiaki,Hasegawa, Aiko,Kuwata, Shigeki,Ishihara, Kazuaki,Yamamoto, Hisashi,Ikariya, Takao
, p. 220 - 224 (2007/10/03)
α-Tocopherol was synthesized using a condensation reaction of 2,3,6-trimethylhydroquinone with isophytol in supercritical CO2 using batch and continuous-flow reactors. In the batch reaction catalyzed by a fluorinated molecular catalyst bearing strong Bronsted acidity, C 6F5CHTf2 (Tf=SO2CF3), an increase in the CO2 pressure causes a marked increase in the product selectivity for α-tocopherol, albeit with a slight decrease in the product yield. The solubility measurements by extraction experiments and the supercritical fluid NMR (scNMR) indicate that the homogeneous and non-polar reaction phase in scCO2 is crucial to obtain α-tocopherol with high selectivity. A continuous flow scCO2 process for the condensation reaction can be performed with a strong acid resin, Amberlyst 15, as a solid acid catalyst to give the desired product with high selectivity.
