185679-35-0

Upstream product

• 3978-80-1 Boc-Tyr-OH 
• 374803-71-1 (S)-2-Benzyloxycarbonylamino-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-propionic acid methyl ester 
• 103788-65-4 (5-methyl-2-phenyloxazol-4-yl)ethanol 
• 13512-31-7 N-(benzyloxycarbonyl)-L-tyrosine methyl ester 
• 196811-04-8 (S)-amino-3-<4-<2-(5-methyl-2-phenyloxazol-4-yl)ethoxy>phenyl>propionic acid methyl ester 

Downstream Products

• 374803-70-0 (2S)-2-[(2-benzoyl-4-{[2-(trimethylsilyl)ethoxy]methoxy}phenyl)amino]-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl}propanoic acid 

Relevant academic research and scientific papers

Substituted oxazoles and thiazoles derivatives as hPPARγ and hPPARα activators

The present invention discloses compounds of formula (I), and tautomeric forms, pharmaceutically acceptable salts, or solvates thereof. Preferably, the compounds of the invention are dual activators of hPPARγ and hPPAR{acute over (α)}.

The synthesis of GW710936X to support the development of potent PPARγ agonists

(2S)-[(2-Benzoyl-4-hydroxy-phenyl)amino]-3-{4-[2-(5-methyl-2-phenyloxazol-4- yl)ethoxy]phenyl}propanoic acid has been synthesised from N-Cbz-L-tyrosine methyl ester utilising a copper(I) catalysed N-arylation as the key coupling step. The synthetic route