185696-46-2

Upstream product

• 2495-35-4 benzylacrylate 
• 185696-45-1 2-iodo-3,5-dimethyl-4-octadecanoylpyrrole 
• 161559-70-2 3,5-dimethyl-4-octadecanoylpyrrole-2-carboxylic acid 
• 161560-34-5 2,4-dimethyl-3-octadecanoylpyrrole 
• 36332-79-3 3,5-dimethyl-4-octadecanoyl-pyrrole-2-carboxylic acid ethyl ester 
• 161560-39-0 3,5-dimethyl-4-octadecanoylpyrrole-2-carbaldehyde 
• 5437-45-6 Benzyl bromoacetate 

Downstream Products

• 185696-48-4 (E)-3-{3,5-Dimethyl-4-octadecanoyl-1-[(E)-(3-phenyl-acryloyl)]-1H-pyrrol-2-yl}-acrylic acid benzyl ester 

Relevant academic research and scientific papers

3-(3,5-Dimethyl-4-octadecanoylpyrrol-2-yl)propionic acids as inhibitors of 85 kDa cytosolic phospholipase A2

3-(1,4-Diacylpyrrol-2-yl)propionic acids were designed as inhibitors of cytosolic phospholipase A2. Enzyme inhibition was assayed by evaluation of calcium ionophore A23187-induced arachidonic acid release from bovine platelets. While the synthesized bisacyl compound 3-[3,5-dimethyl-4-octadecanoyl-1-(3-phenylpropionyl)pyrrol-2-yl]propio nic acid was inactive at 33 μM, the related monoacylated 3-(3,5-dimethyl-4-octadecanoylpyrrol-2-yl) propionic acid and 3-(1,3,5-trimethyl-4-octadecanoylpyrrol-2-yl) propionic acid proved to be inhibitors of cytosolic phospholipase A2 (IC50: 24 μM and 13 μM, respectively).