185760-72-9Relevant academic research and scientific papers
Enzyme-Promoted Direct Asymmetric Michael Reaction by Using Protease from Streptomyces griseus
Wu, Ling-Ling,Li, Ling-Po,Xiang, Yang,Guan, Zhi,He, Yan-Hong
, p. 2209 - 2214 (2017/07/24)
The direct asymmetric Michael addition of malonates and enones was promoted by protease from Streptomyces griseus for the first time. Yields of up to 84% with enantioselectivities of up to 98% enantiomeric excess (ee) were achieved under optimized conditi
Organocatalytic enantioselective Michael additions of malonates to 2-cyclopentenone
Mase, Nobuyuki,Fukasawa, Maho,Kitagawa, Norihiko,Shibagaki, Fumiya,Noshiro, Naoyasu,Takabe, Kunihiko
scheme or table, p. 2340 - 2344 (2010/11/04)
The Michael reaction of a dialkyl malonate with a cyclic enone using a chiral diamine-acid combination catalyst gave the desired Michael adduct in high yield with excellent enantiomeric excess in a protic solvent such as methanol and ethanol. The methanol
Linked-BINOL: An Approach towards Practical Asymmetric Multifunctional Catalysis
Matsunaga, Shigeki,Ohshima, Takashi,Shibasaki, Masakatsu
, p. 3 - 15 (2007/10/03)
The development and application of a novel linked-1,1′-binaphthol (linked-BINOL) as an approach towards practical asymmetric multifunctional catalysis is described. Linked-BINOL was first designed to increase the stability of a Ga-Li-BINOL complex against
Immobilization of asymmetric multifunctional catalysts on an insoluble polymer
Matsunaga,Ohshima,Shibasaki
, p. 8473 - 8478 (2007/10/03)
Polymer-supported linked-BINOL was synthesized to immobilize asymmetric catalysts with two BINOL units. The advantage of the polymer-supported linked-BINOL over randomly polymer-supported BINOL was confirmed by asymmetric Michael reaction. A novel polymer
