185798-88-3

Upstream product

• 872-85-5 pyridine-4-carbaldehyde 
• 96797-15-8 N-trityl-4⁽⁵⁾-iodoimidazole 

Downstream Products

• 1169826-13-4 pyridin-4-yl(1-trityl-1H-imidazol-5-yl)methanone 
• 185798-86-1 4(5)-[1-hydroxy-1-(4-pyridyl)methyl]-1H-imidazole 

Relevant academic research and scientific papers

Unconventional acceptor and donor functional groups linked by a captodative spacer

The chemical stability to oxidation of a set of compounds built up from acceptor and donor subunits linked by a methylene or a hydroxymethylene group was studied. Whereas 1-butyl-3-[1,2,4-triazol-5(3)-ylmethyl]pyridinium salts 2d,e showed high stability to oxidation, 1-butyl-4-[imidazol-4(5)-ylhidroxymethyl]pyridinium salt 14f was oxidised spontaneously to the corresponding carbonyl compound, indicating the capability of the oxidation phenomenon to be controlled by the nature of the building blocks.

SUBSTITUTED-ARYL-2-PHENYLETHYL-1H-IMIDAZOLE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA 2B AND/OR ALPHA 2C ADRENERGIC RECEPTORS

A compound having selective modulating activity at the alpha 2B and/or alpha 2C adrenergic receptor subtypes is represented by the general Formula 1: wherein n=1-4; X is C or N; R1—R6 can be the same or different and are independently selected from the group consisting of H, C1-6 alkyl, OCH3, OH, F, Cl, Br, CH2OH, CH2N(R7)2, C(O)R8, CH2CN, CF3; wherein R7 is H or C1-6 alkyl; and R8 is C1-6 alkyl or aryl. The compounds of Formula 1 can be incorporated in pharmaceutical compositions and used in methods of treatment of alpha 2 receptor mediated diseases and conditions.