185802-89-5

Basic information

• Product Name: [2-(3-Bromo-propoxy)-phenyl]-acetic acid
• CAS NO: 185802-89-5
• Molecular Weight: 273.126
• Mol File: 185802-89-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [2-(3-Bromo-propoxy)-phenyl]-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(3-Bromo-propoxy)-phenyl]-acetic acid(185802-89-5)
• EPA Substance Registry System: [2-(3-Bromo-propoxy)-phenyl]-acetic acid(185802-89-5)

Safety Data

• Hazardous Substances Data: 185802-89-5(Hazardous Substances Data)

Upstream product

• 22446-37-3 methyl (2-hydroxyphenyl)acetate 
• 147106-99-8 [2-(3-bromo-propoxy)-phenyl]-acetic acid methyl ester 

Relevant articles and documents

Synthesis and biological evaluation of phenylacetyl derivatives having low central nervous system permeability as potent and selective M2 muscarinic receptor antagonists

A series of phenylacetyl derivatives containing the 5,10-dihydro-11H- dibenzo[b,e][1,4]diazepin-11-one or 5,11-dihydro-6H-pyrido[2,3- b][1,4]benzodiazepin-6-one skeleton was prepared and evaluated for their binding affinities to muscarinic receptors in vitro and for antagonism of bradycardia, salivation and tremor in vivo. Among them, compounds 56 and 66 had high affinity for M2 muscarinic receptors in the heart (pK(i) = 8.7 and 8.9, respectively) with low affinity for M3 muscarinic receptors in the submandibular gland. A structure-activity relationship (SAR) study suggested that the high M2 selectivity over the M3 muscarinic receptors of 56 may be attributed to the direction of the carboxamide carbonyl group. In in vivo studies, 56 and 66 antagonized oxotremorine-induced bradycardia in rats on both intravenous and oral administration, and their heart rate increasing effect in dogs with nocturnal bradycardia was about 3-fold greater than that of AF-DX 116. Furthermore, they had almost no influence on oxotremorine- induced tremor in mice, presenting no evidence of central transfer.