185804-88-0

Usage

Uses

Used in Pharmaceutical Research and Development:
Urea, N-(6-chloro-2-phenyl-1,3-dioxolo[4,5-b]quinolin-9-yl)-N'-ethyl-N-methylis used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure, which includes a quinoline ring and a dioxoloquinoline ring, makes it a valuable component in the development of new drugs and organic substances.
Used in Organic Chemistry Research:
In the field of organic chemistry, Urea, N-(6-chloro-2-phenyl-1,3-dioxolo[4,5-b]quinolin-9-yl)-N'-ethyl-N-methylis used as a research compound to explore its properties and potential applications. Its structure and reactivity are of interest to chemists working on the synthesis and modification of complex organic molecules.

Upstream product

• 185804-21-1 ethyl 7-chloro-3-hydroxy-2-oxo-1,2-dihydroquinoline-4-carboxylate 
• 618-31-5 benzylidene dibromide 
• 6341-92-0 6-chloroisatin 
• 185804-84-6 6-chloro-2-phenyl-1,3-dioxa-4-aza-cyclopenta[b]naphthalene-9-carboxylic acid 
• 185804-86-8 1-(6-chloro-2-phenyl-1,3-dioxa-4-aza-cyclopenta[b]naphthalen-9-yl)-3-ethyl-urea 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Structure-activity relationships of 3-hydroxy-2(1H)-quinolinones as N-methyl-D-aspartate (glycine site) receptor antagonists

Two series of 3-hydroxy-2(1H)-quinolinones (3a-s, 4a-v) were prepared and structure-activity relationships for binding affinity to the N-methyl-D-aspartate (glycine site) receptor measured. Despite the structural similarity to glycine antagonists of the quinoxalinedione type, surprisingly, the SARs for compounds 3a-s more closely follow those of the kynurenic acids. Thus the most potent compounds, 3r (IC50 = 6.3 nM) and 4v (IC50 = 7.6 nM), possessed chlorines at both 5 and 7 positions, and a suitable hydrogen-bond acceptor (ethoxycarbonyl or N,N′-dialkyl-ureido) at the 4-position.