185853-85-4

Basic information

• Product Name: 2-[3-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL]ETHANOL
• Synonyms: 2-[3-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL]ETHANOL;2-[3-(trifluoromethyl)-1H-pyrazol-4-yl]ethan-1-ol
• CAS NO: 185853-85-4
• Molecular Formula: C6H7F3N2O
• Molecular Weight: 180.1277896
• Mol File: 185853-85-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 274.8±35.0 °C(Predicted)
• Appearance: /
• Density: 1.443±0.06 g/cm3(Predicted)
• PKA: 10.90±0.50(Predicted)
• CAS DataBase Reference: 2-[3-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL]ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL]ETHANOL(185853-85-4)
• EPA Substance Registry System: 2-[3-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL]ETHANOL(185853-85-4)

Safety Data

• Hazardous Substances Data: 185853-85-4(Hazardous Substances Data)

Usage

General Description

2-[3-(trifluoromethyl)-1H-pyrazol-4-yl]ethanol is a chemical compound with the molecular formula C7H8F3NO. It is a colorless liquid with a slightly sweet odor. 2-[3-(trifluoromethyl)-1H-pyrazol-4-yl]ethanol is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential use as a solvent in various chemical processes. The trifluoromethyl group in the molecule makes it a valuable building block for the synthesis of diverse chemical compounds, particularly those used in the field of medicinal chemistry. 2-[3-(trifluoromethyl)-1H-pyrazol-4-yl]ethanol is also known by its CAS number 881681-11-0.

Relevant articles and documents

Synthesis of a series of trifluoromethylazoles and determination of pKa of acidic and basic trifluoromethyl heterocycles by 19F NMR spectroscopy

Trifluoroacetylation at the 5-position of 3,4-dihydro-2H-pyran and the 3-position of 4,5-dihydrofuran, followed by treatment with hydrazine, gave 3-(3-trifluoromethyl-1H-pyrazol-4-yl)propanol and 2-(3-trifluoromethyl-1H-pyrazol-4-yl)ethanol, respectively.In the latter case, an intermediate dimer was isolated.Isomeric 2-(3-trifluoromethyl-1H-pyrazol-5-yl)ethanol was formed by reaction of hydrazine with 6-benzyloxy-1,1,1-trifluorohex-3-yn-2-one and deprotection.Reaction of 3-benzyloxypropylamine with 2,5-bis(trifluoromethyl)-1,3,4-oxadiazole, followed by deprotection, afforded 3-propanol.A series of 2-trifluoromethyl-1H-benzimidazoles and 2-trifluoromethyl-3H-imidazopyridines were prepared by condensation of the appropriate ortho-arenediamine with trifluoroacetic acid.Analysis of the 19F NMR spectra of the trifluoromethylazoles and of 3-trifluoromethylpyridine in aqueous solution at different pHs enabled determination of pKa values.All the compounds evaluated had one or more pKa between 1 and 13, except the triazole.Several compounds were identified as having potential use in measuring pH in biological media by 19F NMR spectroscopy.