18593-68-5Relevant articles and documents
Thieno[2.3-d]-4-pyrimidones: Synthesis, structure and pharmacological properties
Perrissin,Favre,Luu-Duc,et al.
, p. 420 - 424 (2007/10/02)
The cyclization of 2-amino-3-carbethoxy or -carboxamido thophenes yields substituted or unsubstituted 4-pyrimidones. Their structure and their 'lactam-lactam' tautomerism have been investigated by i.r. spectroscopy. The eighteen compounds synthesized were tested for a few pharmacological activities. They have no anti-edema activity except for two. Ten of them have shown an analgesic activity equal or superior to that of acetyl salicylic acid.