18598-12-4

Upstream product

• 68055-31-2 N-benzyl-4-methoxybenzenecarbothioamide 

Downstream Products

• 23574-20-1 2-(4-methoxy-phenyl)-benzo[e][1,3]thiazin-4-one 
• 25082-98-8 2-(4-methoxy-phenyl)-1-oxo-2,3-dihydro-1H-1λ⁴-benzo[e][1,3]thiazin-4-one 

Relevant academic research and scientific papers

Intramolecular dehydrogenative C-S bond coupling of thioamides to form 1,3-benzothiazines under metal-free conditions

A novel HTIB-promoted direct intramolecular dehydrogenative C-S bond coupling reaction of thioamides has been developed to provide 1,3-benzothiazine derivatives in good yields. The reaction proceeds smoothly to reach completion at room temperature within 1 min under metal-free conditions. This protocol provides a mild and efficient strategy for the synthesis of six-membered N,S-containing heterocycles. Preliminary mechanistic studies indicate that a spirocyclic intermediate might be involved.

Benzothiazine compound preparation method

The invention discloses a benzothiazine compound preparation method, which belongs to the technical field of organic synthesis. The method is characterized in that thioamide, hydroxy(tosyloxy)iodo benzene, and a solvent are added in a reactor, after the r