186033-90-9Relevant academic research and scientific papers
Pyrrole derivatives and medicinal composition
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, (2008/06/13)
The invention relates to a pharmaceutical composition comprising a pyrrole derivative of the following formula [1] or a pharmaceutically acceptable salt thereof, or a solvate of either of them, as an active ingredient. STR1 (wherein R1 represents hydrogen or alkoxycar91 bonylamino, R2 represents alkyl, aryl which may be substituted, aromatic heterocyclyl which may be substituted, unsubstituted amino, monoalkylamino, dialkylamino, or cyclic amino which may be substituted; R3 represents cyano or carbamoyl; R4 represents hydrogen or alkyl; E represents alkylene; q is equal to 0 or 1, A represents methyl, aryl which may be substituted, or aromatic heterocyclyl which may be substituted). The pharmaceutical composition of the invention is effective for the treatment of pollakiuria or urinary incontinence.
Pyrrolo[2,1-d][1,2,3,5]tetrazines, a new class of azolotetrazines related to the antitumor drug temozolomide
Diana, Patrizia,Barraja, Paola,Lauria, Antonino,Almerico, Anna Maria,Dattolo, Gactano,Cirrincione, Girolamo
, p. 2082 - 2086 (2007/10/03)
A series of derivatives of the new ring system pyrrolo[2,1- d][1,2,3,5]tetrazine, potential antineoplastic agents, were obtained in good yield from the reaction of 2-diazopyrroles with isocyanates at room temperature and in the dark. Atomic charges at C-4
