186094-10-0Relevant articles and documents
Synthesis and biological evaluation of novel delta (δ) opioid receptor ligands with diazatricyclodecane skeletons
Loriga, Giovanni,Lazzari, Paolo,Ruiu, Stefania,Marchese, Giorgio,Manca, Ilaria,Casu, Gian Luca,Dessì, Christian,Pinna, Gérard Aimè,Asproni, Battistina,Murineddu, Gabriele
, p. 413 - 426 (2013/10/22)
Considering the interesting pharmacological profile of the delta (δ) selective opioid agonist compound SNC-80, conformationally constrained analogs containing two diazatricyclodecane ring systems in place of dimethylpiperazine core motif were synthesized.
Diazacyclic compounds having affinity for opioid receptors
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Page/Page column 70, (2011/07/09)
Diazapolycyclic compounds having affinity for the opioidergic receptors, preferably for the delta opioidergic receptors, with central and/or peripheral activity, having formula: ???????? A1-D1-T1?????(I) wherein: - A1 is a group of formula (II): wherein: R1 is phenyl wherein one of the ring hydrogen atoms is substituted with a group selected from C(O)R', C(O)OR', C(O)NHR' or C(O)NR3R4, R', R3 and R4, being as defined in the application; R2 is phenyl, optionally substituted - D1 is a diazapolycyclic group - T1 is a group selected from H, alkyl, alkenyl, alkynyl and from the following optionally substituted groups: cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl or heteroarylalkyl, and their hydrates and solvates and pharmaceutically acceptable salts.
Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic δ opioid receptor ligands
Zhang, Xiaoyan,Rice, Kenner C.,Calderon, Silvia N.,Kayakiri, Hiroshi,Smith, Larren,Coop, Andrew,Jacobson, Arthur E.,Rothman, Richard B.,Davis, Peg,Dersch, Christina M.,Porreca, Frank
, p. 5455 - 5463 (2007/10/03)
We recently reported (+)-4-[(αR)-α-{(2S,5R)-4-allyl-2,5- dimethyl-1-piperazinyl}-3-methoxybenzyl]-N,N-diethylbenzamide (1b, SNC80) as a novel nonpeptidic δ receptor agonist and explored the structure-activity relationships (SAR) of a series of related der