18615-08-2

Basic information

• Product Name: [carboxyl-14C]-methyl benzoate
• Synonyms: [carboxyl-14C]-methyl benzoate
• CAS NO: 18615-08-2
• Molecular Weight: 138.139
• Mol File: 18615-08-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [carboxyl-14C]-methyl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: [carboxyl-14C]-methyl benzoate(18615-08-2)
• EPA Substance Registry System: [carboxyl-14C]-methyl benzoate(18615-08-2)

Safety Data

• Hazardous Substances Data: 18615-08-2(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 1589-66-8 [carbonyl-(14)C]benzoic acid 
• 67-56-1 methanol 
• 591-50-4 iodobenzene 
• 51-90-1 [14C]carbon dioxide 

Downstream Products

• 1313403-82-5 dimethylsulfoxonium [2-⁽¹⁴⁾C]2-phenyl-2-oxoethylide 
• 14734-27-1 [carbonyl‐¹⁴C] benzaldehyde 
• 611-95-0 4-carboxybenzophenone 
• 13057-53-9 [1-¹⁴C]benzyl alcohol 

Relevant articles and documents

A convenient method for [14C]Carbonylation reactions

A simple, efficient method for generation of 14CO from Ba14CO3 has been developed. Reduction of 14CO2 using LiBEt3H gave [14C]formate in good yield which was treated with conc. H2SO4 to effect dehydration to 14CO. Through direct attachment of a reaction vessel containing aryl substrate and Pd(0) catalyst, [14C]carbonylation reactions were performed without the use of a mercury transfer pump. [14C]Carbonylation reactions using 14CO generated in this manner have been shown to proceed in good yield with a variety of substrates.

Synthesis of optically pure (D-phenyl[3-14C]alanine

Lithium aluminium hydride reduction of methyl [7-14C]benzoate gave [7-14C]benzyl alcohol which was transformed (HBr, H2SO4) to [7-14C]benzyl bromide. The latter was reacted with lithium N-(bis-methylt