186181-88-4Relevant academic research and scientific papers
Macrocyclic peptide inhibitors of serine proteases. Convergent total synthesis of cyclotheonamides A and B via a late-stage primary amine intermediate. Study of thrombin inhibition under diverse conditions
Maryanoff, Bruce E.,Greco, Michael N.,Zhang, Han-Cheng,Andrade-Gordon, Patricia,Kauffman, Jack A.,Nicolaou,Liu, Aijun,Brungs, Peter H.
, p. 1225 - 1239 (2007/10/02)
Cyclotheonamide A (CtA, 1), a cyclic pentapeptide isolated from the marine sponge Theonella sp., is an inhibitor of serine proteases such as α-thrombin and trypsin. We describe, in detail, our total synthesis of CtA by a convergent [3 + 2] fragment-conden
