186199-35-9

Upstream product

• 121618-58-4 trans-tert-butyldimethyl(((2S,3S)-3-phenyloxiran-2-yl)methoxy)silane 
• 37434-59-6 dimethyl 2-phenylmalonate 
• 173423-55-7 3-((tert-butyldimethylsilyl)oxy)-2-phenylpropan-1-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1027225-90-6 (E)-5-(tert-Butyl-dimethyl-silanyloxy)-4-phenyl-pent-2-enoic acid methyl ester 
• 199191-19-0 N-[3-(tert-butyldimethylsiloxy)-2-phenylpropylidene]benzylamine N-oxide 
• 1124258-45-2 C₂₄H₃₄OSi 
• 173423-62-6 methyl (+/-)-(2E)-5-(bromoacetoxy)-4-phenyl-2-pentenoate 
• 173423-57-9 (+/-)-1-(2'-bromo-1'-ethoxyethoxy)-2-phenyl-3-butene 
• 173423-61-5 (+/-)-(2Z)-1-(bromoacetoxy)-2-phenyl-3-pentene 
• 173423-60-4 (+/-)-1-(bromoacetyloxy)-2-phenyl-3-butene 
• 173423-56-8 (+/-)-(3Z)-2-phenyl-3-penten-1-ol 
• 172223-20-0 methyl (+/-)-(2E)-5-hydroxy-4-phenyl-2-pentenoate 
• 6052-63-7 2-phenylbut-3-en-1-ol 

Relevant academic research and scientific papers

TETRAHYDRO-IMIDAZO QUINOLINE COMPOSITIONS AS CBP/P300 INHIBITORS

The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.

New general method for regio- and stereoselective allylic substitution with aryl and alkenyl coppers derived from grignard reagents

Allylic substitution with sp2-carbon reagents (aryl and alkenyl anions) was realized by using allylic picolinates and copper reagents derived from RMgBr and CuBr-Me2S to afford anti SN2 products regioand stereoselectively. Steric and electronic factors in the reagents and the size of the methylene substituents around the allylic moiety marginally affected the selectivity. The reaction system was compatible with alkyl reagents as well. Furthermore, the substitution was applied to construction of a quaternary center and synthesis of (-)-sesquichamaenol. Electron-withdrawing nature of the pyridyl group and chelation of the C(=O)-C5H4N to MgBr2 generated in situ were found to be responsible for the high efficiency of the substitution.

Highly regio- and stereoselective rearrangement of epoxides to aldehydes catalyzed by high-valent metalloporphyrin complex, Cr(TPP)OTf

Chromium(III) tetraphenylporphyrin triflate, Cr(TPP)OTf, works as an efficient and characteristic Lewis acid catalyst in the regio- and stereoselective rearrangement of epoxides to aldehydes. This Cr(TPP)OTf-catalyzed reaction is an operationally simple a

Influence of a 2-fluoro substituent on diastereoselectivity in the 1,3-dipolar cycloadditions of nitrones

It is clear that the role of 1,2-asymmetric induction on the 1,3-dipolar cycloaddition of nitrones is influenced by the presence of a fluorine atom at the C-2 position. 2-Fluoro nitrones, synthesized by three different methods, have been subjected to the intermolecular 1,3-dipolar cycloaddition with ethyl vinyl ether. The stereostructures of isoxazolidines formed were determined by their conversion into 2,7-dioxa-6-azabicyclo[3.2.1]octanes. The diastereoselectivity of 2-fluoro nitrones was the reverse of that of the corresponding 2-hydro nitrones. This fact supports that the conformation with relief from the dipole repulsion between the fluorine atom and the oxygen atom of the nitrone is a preferred one for 2-fluoro nitrones, while the corresponding 2-hydro nitrones adopt the conformation with the least 1,3-allylic strain.

Metalloporphyrin as an efficient catalyst in the regioselective isomerization of epoxides to carbonyl compounds

Regioselective ring-opening isomerization of epoxides to carbonyl compounds can effectively be catalyzed by iron (III) tetraphenylporphyrin, Fe(tpp)ClO4.

Synthesis of six-membered compounds by environmentally friendly cyclization using indirect electrolysis

[Ni(cyclam)](ClO4)2-catalyzed indirect electroreduction of olefinic bromides produced six-membered compounds in low to high yields. The synthetic intermediate 49 of Ipecac and Corynanthe alkaloids was obtained in 88% yield in a highly stereoselective manner. Lactam 66, the synthetic precursor of tacamonine, was prepared in 49% yield as a mixture of two diastereoisomers. The electrolysis of the bromoacetates gave the debrominated compounds in good yields.