186202-03-9Relevant articles and documents
Synthesis and structure-activity relationships of 2-pyridones: II. 8- (fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents
Li, Qun,Wang, Weibo,Berst, Kristine B.,Claiborne, Akiyo,Hasvold, Lisa,Raye, Kathleen,Tufano, Michael,Nilius, Angela,Shen, Linus L.,Flamm, Robert,Alder, Jeff,Marsh, Kennan,Crowell, DeAnne,Chu, Daniel T.W.,Planner, Jacob J.
, p. 1953 - 1958 (2007/10/03)
The 8-position side chain of 2-pyridones is believed to be involved in the binding with bacterial DNA gyrase to form the ternary complex, making them very important for the activity of 2-pyridones. A series of 2-pyridones having fluoro-substituted amines at the 8-position has been synthesized and their antibacterial activities and parmacokinetic properties are reported.
