186262-54-4Relevant academic research and scientific papers
Design and synthesis of novel quinoxaline-2,3-dione AMPA/Gly(N) receptor antagonists: Amino acid derivatives
Nikam, Sham S.,Cordon, John J.,Ortwine, Daniel F.,Heimbach, Tycho H.,Blackburn, Anthony C.,Vartanian, Mark G.,Nelson, Carrie B.,Schwarz, Roy D.,Boxer, Peter A.,Rafferty, Michael F.
, p. 2266 - 2271 (2007/10/03)
PNQX (1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]quinoxaline- 2,3-dione) is a potent AMPA (IC50 = 0.063 μM) and Gly(N) (IC50 = 0.37 μM) receptor antagonist that was developed in our laboratories. While possessing a desirable
