186293-26-5Relevant articles and documents
Silver(I) complexes with symmetrical Schiff bases: Synthesis, structural characterization, DFT studies and antimycobacterial assays
Paiva, Isabela L.,De Carvalho, Gustavo S.G.,Da Silva, Adilson D.,Corbi, Pedro P.,Bergamini, Fernando R.G.,Formiga, André L.B.,Diniz, Renata,Do Carmo, Weberton R.,Leite, Clarice Q.F.,Pavan, Fernando R.,Cuin, Alexandre
, p. 104 - 109 (2013)
Synthesis, structural and spectroscopic characterizations, molecular modeling and antimycobacterial assays of new silver(I) complexes with two Schiff bases - MBDA and MBDB - are reported. The complexes [Ag(MBDA) 2]NO3, or AgMBDA, and
Modeling and biological evaluation of 3,3′-(1,2-ethanediyl)bis[2-(4-methoxyphenyl)-thiazolidin-4-one], a new synthetic cyclooxygenase-2 inhibitor
Ottaná, Rosaria,Mazzon, Emanuela,Dugo, Laura,Monforte, Francesca,Maccari, Rosanna,Sautebin, Lidia,De Luca, Grazia,Vigorita, Maria Gabriella,Alcaro, Stefano,Ortuso, Francesco,Caputi, Achille P,Cuzzocrea, Salvatore
, p. 71 - 80 (2002)
Within the series of chiral 3,3′-(1,2-ethanediyl)bis[2-arylthiazolidin-4-ones], the 3,4-dimethoxyphenyl substituted derivative was found in the primary anti-inflammatory screening to be endowed with superior in vivo properties and good safety profile. Suc
Conformational and structural analysis of N-N′-bis (4-methoxybenzylidene)ethylenediamine
ünalero?lu,Temelli,H?kelek
, p. 91 - 95 (2001)
The Schiff base compound, N-N′-bis(4-methoxybenzylidene)ethylenediamine (C18H20N2O2) has been synthesized and its crystal structure has been investigated by X-ray analysis and PM3 method. The compound crystalliz
Design, synthesis and biological evaluation of Schiff’s base derivatives as multifunctional agents for the treatment of Alzheimer’s disease
Shi, Jian,Zhou, Yi,Wang, Keren,Ma, Qinge,Wei, Rongrui,Li, Qingfeng,Zhao, Yiyang,Qiao, Zhanpin,Liu, Shuang,Leng, Yumin,Liu, Wenmin,Sang, Zhipei
, p. 624 - 634 (2020/11/30)
A series of Schiff’s base derivatives was rationally designed, synthesized, and evaluated as multi-function agents for the treatment of Alzheimer’s disease (AD). The results revealed that compound 3b was a novel multifunctional agent. It acted as a highly selective monoamine oxidase-B inhibitor (IC50 = 8.4 nM), which was explained by the docking study. Compound 3b also was an antioxidant agent (2.3 eq) and could significantly inhibit self-induced Aβ1-42 aggregation (31.8%). Meanwhile, compound 3b was a selective metal chelator and could inhibit Cu2+-induced Aβ1-42 aggregation (62.3%). Furthermore, compound 3b presented good neuroprotective effects on H2O2-induced PC12 cell injury. More importantly, compound demonstrated good blood brain barrier permeability and druglike properties. Therefore, compound 3b, a promising multi-targeted active molecule, offers an attractive starting point for further study in the drug-discovery process against AD.[Figure not available: see fulltext.].
Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1
Kishk, Safaa M.,McLean, Kirsty J.,Sood, Sakshi,Helal, Mohamed A.,Gomaa, Mohamed S.,Salama, Ismail,Mostafa, Samia M.,de Carvalho, Luiz Pedro S.,Munro, Andrew W.,Simons, Claire
supporting information, p. 1546 - 1561 (2019/03/05)
The rise in multidrug resistant (MDR) cases of tuberculosis (TB) has led to the need for the development of TB drugs with different mechanisms of action. The genome sequence of Mycobacterium tuberculosis (Mtb) revealed twenty different genes coding for cy
Molybdenum-catalyzed diastereoselective anti-dihydroxylation of secondary allylic alcohols
Su, Shixia,Wang, Chuan
supporting information, p. 2436 - 2440 (2019/03/29)
In this protocol, we report a Mo-catalyzed anti-dihydroxylation of secondary allylic alcohols, providing a general method for the preparation of 1,2,3-triols bearing up to three continuous stereocenters with excellent diastereocontrol. The mechanistic studies reveal that this dihydroxylation reaction consists of two steps and up to excellent diastereomeric ratios of the final triol products can be achieved due to the high level of both diastereocontrol in the initial epoxidation and regiocontrol in the following hydrolysis in situ.
