186298-52-2Relevant academic research and scientific papers
Direct iodination of 3- and 4-nitropyrazoles with a reagent based on iodine monochloride and silver sulfate
Chaikovskii,Kharlova,Tretyakov,Vasilevsky,Filimonov
, p. 1475 - 1477 (2000)
The reagent obtained from iodine monochloride and silver sulfate in sulfuric acid easily iodinates 1-methyl-3-nitropyrazole under mild conditions to give 4-iodo or 4,5-diiodo derivatives. 1-Methyl-4-nitropyrazole was also directly iodinated with this reagent for the first time.
Nitrodeiodination of 4-iodo-1-methylpyrazoles
Tret'yakov,Vasilevsky
, p. 2581 - 2584 (1996)
4-Iodo-1-methylpyrazoles react with a nitrating mixture at 55°C to give the corresponding 4-nitro-1-methylpyrazoles. The qualitative dependence of the nitrodeiodination rate on the structure of the heterocycles and the reaction conditions was considered.
Compound as well as preparation method and medical application thereof
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Paragraph 0396-0399, (2020/02/14)
The invention provides a compound as well as a preparation method and medical application thereof, the compound has a structure as shown in a general formula (I), and can also be a tautomer, a mesomer, a raceme, an enantiomer, a diastereoisomer, or a mixture form thereof, or a pharmaceutically acceptable salt thereof. According to the compound with the structure as shown in the general formula (I)provided by the invention, a specific main chain structure and a corresponding substituent group are selected, so that the obtained compound can be used as an arginase inhibitor, is relatively high in activity, and has a potential treatment prospect in various diseases.
COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
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Paragraph 0383, (2017/02/24)
Compounds of Formula (I) or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein A, J, R1, R2, R3, R4, R5, R6, R7, R9, X, m and n are as described herein, compositions thereof, and methods and uses thereof.
