186320-10-5

Usage

Uses

Used in Pharmaceutical Industry:
4-[(FURAN-2-YLMETHYL)-CARBAMOYL]-BUTYRIC ACID is used as a pharmaceutical candidate for its potential therapeutic effects in various medical conditions. Its unique structure and properties make it a valuable asset in drug design and development, where it may contribute to the creation of novel treatments.
Used in Chemical Synthesis:
In the chemical industry, 4-[(FURAN-2-YLMETHYL)-CARBAMOYL]-BUTYRIC ACID is utilized as a chemical intermediate. It plays a crucial role in the synthesis of various organic compounds, facilitating the production of a wide array of chemical products.
Further research and experimentation are necessary to fully understand and harness the potential of 4-[(FURAN-2-YLMETHYL)-CARBAMOYL]-BUTYRIC ACID across different applications, ensuring its safe and effective use in various industries.

Upstream product

• 108-55-4 glutaric anhydride, 
• 617-89-0 furan-2-ylmethanamine 

Relevant academic research and scientific papers

Traceless Release of Alcohols Using Thiol-Sensitive Oxanorbornadiene Linkers

A class of ester-amide oxanorbornadiene (EA-OND) molecules was developed to release alcohol cargos by succinimide formation upon addition of a thiol reagent. The resulting ring-closed adducts undergo further fragmentation by retro-Diels-Alder reaction to release a furan moiety in a manner similar to oxanorbornadiene diesters. The rates of each of these fragmentation pathways in the same medium were found to be sensitive to the steric nature of the amide substituent. Alcohol release was much faster in protic solvents than in aprotic ones, suggesting that this system may be useful for rapid response to thiols in biological environments. Accordingly, the attachment and thiol-dependent release of cholesterol was characterized as an example of the manipulation of a drug-like cargo.

NUCLEOPHILE-TRIGGERED DEGRADBLE MATERIALS AND METHODS OF MAKING AND USING THE SAME

Disclosed herein are degradable materials comprising the reaction product of an oxanorbomadiene crosslinker or derivative thereof and a multivalent nucleophile-terminated compound, wherein the reaction product is a degradable elastic solid capable of entraining cargo. Also disclosed herein are degradable materials comprising a polymeric and hyperbranched crosslinked material made with oxanorbomadiene linkage that can be activated for cleavage at a predetermined rate by addition of a nucleophile. Also disclosed herein are methods of making and using the same.