186341-01-5Relevant academic research and scientific papers
HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS AND COMBINATIONS THEREOF
-
Page/Page column 301, (2015/07/07)
Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.
Summary -Reaction of various N-methyl-substituted 5-atninobenzazoles with ethoxymethylene derivatives of pentane-2,4-dione and 3-oxobutanoic acid
Milata, Viktor,Ilavsky, Dusan,Goljer, Igor,Lesko, Jan,Henry-Basch, Erica,Barry, Jean
, p. 897 - 902 (2007/10/03)
Reaction of 5-amino-l-methylbenzimidazole la, 5-amino-l-methylbenzotriazole Ib or 5-amino-2-methylbenzotriazole le with alkoxymethylene derivatives of pentane-2,4-dione, 3-oxobutanenitrile, methyl or ethyl 3-oxobutanoates yielded the products of nudeophilic substitution (3-6). The structures of derivatives 3-6 are discussed on the basis of their spectral characteristics: IR, UV, 1H NMR, 13C NMR and mass spectra. Elsevier.
