186386-95-8

Usage

Piperazine derivative

A chemical compound derived from piperazine
This indicates that the compound is structurally related to piperazine, a heterocyclic amine with various applications in the pharmaceutical industry.

Trifluoromethoxyphenyl group

A functional group attached to the piperazine ring
This functional group consists of a phenyl ring with a trifluoromethoxy (OCF3) substituent, which may contribute to the compound's biological activity and potential therapeutic applications.

Pharmaceutical research and drug development

Potential use in the treatment of various diseases and disorders
This highlights the compound's potential as a target for developing new drugs to treat a range of medical conditions.

Medicinal chemistry and drug design

Applications in these fields
The compound may be used as a starting point or building block for designing new drugs with improved properties or targeting specific biological pathways.

Building block

Used in the synthesis of other organic compounds
This suggests that the compound can be further modified or combined with other molecules to create new compounds with different properties or applications.

Scientific community interest

Potential pharmacological properties and therapeutic applications
The compound has garnered attention from researchers due to its possible effects on biological systems and its potential to be developed into a therapeutic agent for various diseases and disorders.

Upstream product

• 1535-75-7 2-trifluoromethoxy aniline 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 110-85-0 piperazine 
• 450-96-4 o-chloro-α,α,α-trifluoromethoxybenzene 
• 64115-88-4 1-bromo-2-(trifluoromethoxy)benzene 

Downstream Products

• 433214-38-1 1-(2-hydroxyethyl)-4-(2-trifluoromethoxyphenyl)piperazine 
• 335087-45-1 8-{3-[4-(2-trifluoromethoxyphenyl)-1-piperazinyl]-propylcarbamoyl}-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran 
• 433214-30-3 1-[N-(2-trifluoromethoxyphenyl)-2-aminoethyl]-4-(2-trifluoromethoxyphenyl)piperazine 
• 454445-16-0 [1-(4-Chloro-phenyl)-cyclobutyl]-{3-[4-(2-trifluoromethoxy-phenyl)-piperazin-1-ylmethyl]-piperidin-1-yl}-methanone 

Relevant academic research and scientific papers

Heteroaromatic acetamide derivative, preparation and applications thereof

The present invention provides a heteroaromatic acetamide derivative, a preparation and applications thereof, wherein the derivative comprises a pharmaceutically acceptable salt and/or a solvate thereof. According to the present invention, the experiment results prove that the heteroaromatic acetamide derivative can specifically bind to transient receptor potential ankyrin 1 (TRPA1) and inhibit orreduce the activity of TRPA1, and can be used for treating diseases mediated by TRPA1; and the inhibitor of the present invention further comprises a pharmaceutical composition of the compound, and amethods for preparing the compounds. The derivative has a general formula defined in the specification.

5-[3-[PIPERAZIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS

The present invention discloses 5-[3-[piperazin-l-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives according to Formula (I), wherein R1, R2, R3a, R3b, R6a, R6b, the subscript n and Cy are as defined herein. The present invention relates to compounds inhibiting ADAMTS 4 and 5 for the prophylaxis or treatment of inflammatory diseases or diseases involving degradation of cartilage or disruption of cartilage homeostasis, such as e.g. osteoarthritis.

Pd-Catalyzed Synthesis of Piperazine Scaffolds under Aerobic and Solvent-Free Conditions

A facile Pd-catalyzed methodology providing an efficient synthetic route to biologically relevant arylpiperazines under aerobic conditions is reported. Electron donating and sterically hindered aryl chlorides were aminated to afford yields up to 97%, with examples using piperazine as solvent, illustrating an ecofriendly, cost-effective synthesis of these privileged structures.

Identification of novel GLUT inhibitors

The compound class of 1H-pyrazolo[3,4-d]pyrimidines was identified using HTS as very potent inhibitors of facilitated glucose transporter 1 (GLUT1). Extensive structure–activity relationship studies (SAR) of each ring system of the molecular framework was established revealing essential structural motives (i.e., ortho-methoxy substituted benzene, piperazine and pyrimidine). The selectivity against GLUT2 was excellent and initial in vitro and in vivo pharmacokinetic (PK) studies are encouraging.

Practical method for parallel synthesis of diversely substituted 1-phenylpiperazines

A simple and practical method to prepare 'libraries' of substituted 1-phenylpiperazine building blocks in parallel format has been developed.

N-Arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective α1-adrenoceptor antagonists

Novel arylpiperazines were identified as α1-adrenoceptor (AR) subtype- selective antagonists by functional in vitro screening. 3-[4-(ortho- Substituted phenyl)piperazin-1:yl]propylamines were derivatized with N,N- dimethyl anthranilamides, nicotinamides, as well as carboxamides of quinoline, 1,8-naphthyridine, pyrazolo[3,4-b]pyridine, isoxazolo[3,4- b]pyridine, imidazo[4,5-b]pyridine, and pyrazolo[1,5-a]pyrimidines. Strips of rabbit bladder neck were employed as a predictive assay for antagonism in the human lower tract. Rings of rat aorta were used as a 'negative screen' for the test antagonists. Binding to α1-ARs was relatively sensitive to size and electronic features of the arylpiperazine portion of the antagonists and permissive to these features on the heteroaryl carboxamide side. These structure-affinity findings were exploited to produce nicotinamides (e.g. 13ii and 25x) and pyrazolo[3,4-b]pyridines (e.g. 37f and 37y) ligands with nanomolar affinity at the α1-AR subtype prevalent in the human lower urinary tract (pA2 values: 8.8, 10.7, 9.3, and 9.9, respectively) and displaying 2-3 orders of magnitude selectivity over the α(1D)-AR.