18640-74-9

Usage

Uses

Used in Flavor Industry:
2-Isobutylthiazole is used as a flavor component for its ability to enhance the aroma of ripe tomatoes. It is commonly utilized in the flavors of blackcurrant, papaya, melon, raspberry, and roast beef, as well as in fresh lime.
Used in Food Industry:
2-Isobutylthiazole is used as an additive to impart a tomato leaf-like aroma to various food products, contributing to a more appealing and natural taste experience.
Aroma Threshold Values:
The detection threshold of 2-Isobutylthiazole is 3.5 ppb, indicating that it can be detected at very low concentrations, making it an effective flavor enhancer even in small amounts.

Preparation

By cyclization of aliphatic amides with α,β-dibromo ether.

InChI:InChI=1/C7H11NS/c1-6(2)5-7-8-3-4-9-7/h3-4,6H,5H2,1-2H3

Upstream product

• 69749-91-3 2-(methanesulfonyl)thiazole 
• 78-77-3 Isobutyl bromide 

Downstream Products

• 1255536-55-0 1-(4-(2-isobutylthiazol-5-yl)phenyl)ethan-1-one 
• 1404074-50-5 3-(2-isobutylthiazol-5-yl)benzonitrile 
• 1404074-51-6 methyl 4-(2-isobutylthiazol-5-yl)benzoate 
• 1404074-47-0 4-(2-isobutylthiazol-5-yl)benzonitrile 
• 1404074-52-7 C₁₄H₁₄N₂S 
• 1404074-48-1 4-(2-isobutylthiazol-5-yl)benzaldehyde 
• 1404074-49-2 5-(4-nitrophenyl)-2-isobutylthiazole 
• 1448449-10-2 2-isobutyl-5-(2-(pyridin-2-yl)phenyl)thiazole 
• 1448449-16-8 5,5'-(2-(pyridin-2-yl)-1,3-phenylene)bis(2-isobutylthiazole) 
• 1259389-29-1 5-(4-(trifluoromethyl)phenyl)-2-isobutylthiazole 
• 1259389-30-4 3-(4-(trifluoromethyl)phenyl)-2-methylindolizine 
• 55377-77-0 5-(4-(trifluoromethyl)phenyl)furan-2-carbaldehyde 
• 1127217-52-0 2-propyl-5-(4-(trifluoromethyl)phenyl)thiophene 
• 1236376-45-6 phenyl (E)-3-(2-isobutylthiazol-5-yl)acrylate 

Related news

Corrosion inhibition of X65 steel in sulfuric acid by two food flavorants 2-Isobutylthiazole (cas 18640-74-9) and 1-(1,3-Thiazol-2-yl) ethanone as the green environmental corrosion inhibitors: Combination of experimental and theoretical researches09/07/2019

Food flavors of 2-isobutylthiazole (ITT) and 1-(1,3-Thiazol-2-yl)ethanone (TEO) for the corrosion inhibition of X65 steel in H2SO4 were studied by electrochemical methods, atomic force microscopy (AFM), scanning electron microscopy (SEM) and theoretical calculations. Electrochemical experiments ...detailed

Relevant academic research and scientific papers

Preparation method of 2-alkyl substituted thiazole compound

The invention discloses a preparation method of a 2-alkyl substituted thiazole compound, which comprises the following steps: oxidizing 2-alkyl thiothiazole into 2-alkyl sulfonyl thiazole, mixing the 2-alkyl sulfonyl thiazole with a Grignard reagent, reacting the mixture at 0-5 DEG C, heating the mixture to room temperature to continue the reaction; then adding an acid solution and continuously reacting the components at room temperature to obtain a 2-alkyl substituted thiazole compound, wherein the structural formula of the 2-alkyl thiothiazole is that a Grignard reagent of the 2-alkyl sulfonyl thiazole is RCH2MgX, R1 is selected from C1-C4 alkyl groups, R is selected from H and C1-C4 alkyl groups, and X is halogen. According to the present invention, the use of the expensive palladium catalyst and the ligand is avoided, the use of the poor safety butyl lithium reagent is avoided, the ultra-low temperature of-78 DEG C is not required, the cheap and easily available 2-alkylthiothiazole is adopted as the starting material, the 2-alkyl substituted thiazole compound can be prepared under the milder condition, and the method is suitable for the industrial production.

Thiazole, imidazole and oxazole compounds and treatments of disorders associated with protein aging

Provided are, among other things, compounds of formula I or IA, . Also provided are methods of treatment with such compounds.

Method for treating glaucoma IIB

Provided is a method of decreasing intraocular pressure or improving ocular accommodation in an animal, including a human, comprising administering an intraocular pressure decreasing amount or ocular accommodation improving amount of a compound of the formula I or IA, wherein J is oxygen, sulfur, or N—Rd.