18642-44-9

Basic information

• Product Name: Actein
• Synonyms: (3beta,12beta,16beta,23r,24r,25s,26s))-12-(acetyloxy)-16,23:23,26:24,25-triepoxy-26-hydroxy-9,19-cycloanostan-3-yl beta-d-xylopyranoside;9,19-CYCLOLANOSTANE-BETA-D-XYLOPYRANOSIDE;ACTEIN;12β-Acetoxy-16,23:23,26:24,25-triepoxy-26-hydroxy-9,19-cyclo-5α-lanostan-3β-yl β-D-xylopyranoside;Actein (20 mg);b-D-Xylopyranoside, (3b,12b,16b,23R,24R,25S,26S)-12-(acetyloxy)-16,23:23,26:24,25-triepoxy-26-hydroxy-9,19-cyclolanostan-3-yl;Spiro[5H-cyclopropa[1',8'a]naphth[2',1':4,5]indeno[2,1-b]pyran-10(2H),2'-[3,6]dioxabicyclo[3.1.0]hexane] β-D-xylopyranoside deriv
• CAS NO: 18642-44-9
• Molecular Formula: C₃₇H₅₆O₁₁
• Molecular Weight: 676.83
• Product Categories: Substrates
• Mol File: 18642-44-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 246-250°C
• Appearance: Brown powder
• Density: 1.36
• Refractive Index: 1.61
• PKA: 12.14±0.70(Predicted)
• CAS DataBase Reference: Actein(CAS DataBase Reference)
• NIST Chemistry Reference: Actein(18642-44-9)
• EPA Substance Registry System: Actein(18642-44-9)

Safety Data

• Hazardous Substances Data: 18642-44-9(Hazardous Substances Data)

Usage

Uses

Actein is used as a gamma secretase modulators derived from botanicals.

InChI:InChI=1/C37H56O11/c1-17-12-37(29-34(7,47-29)30(42)48-37)46-20-13-32(5)22-9-8-21-31(3,4)23(45-28-27(41)26(40)19(39)15-43-28)10-11-35(21)16-36(22,35)14-24(44-18(2)38)33(32,6)25(17)20/h17,19-30,39-42H,8-16H2,1-7H3/t17-,19-,20?,21+,22+,23+,24-,25+,26+,27-,28+,29?,30?,32+,33-,34?,35-,36+,37?/m1/s1

Upstream product

• 66176-93-0 cimicifugoside 

Related news

Actein (cas 18642-44-9) inhibits the Na+-K+-ATPase and enhances the growth inhibitory effect of digitoxin on human breast cancer cells09/26/2019

The Na+-K+-ATPase is a known target of cardiac glycosides such as digitoxin and ouabain. We determined that the enzyme also is a target of the structurally-related triterpene glycoside actein, present in the herb black cohosh. Actein’s inhibition of Na+-K+-ATPase activity was less potent than t...detailed

Actein (cas 18642-44-9) induces calcium release in human breast cancer cells09/24/2019

BackgroundThe triterpene glycoside actein from the herb black cohosh preferentially inhibits the growth of breast cancer cells and activates the ER stress response. The ER IP3 receptor and Na,K-ATPase form a signaling microdomain. Since actein is lipophilic, its action may be limited by bioavail...detailed

Actein (cas 18642-44-9) enhances TRAIL effects on suppressing gastric cancer progression by activating p53/Caspase-3 signaling09/10/2019

Actein (ACT), isolated from the rthizomes of Cimicifuga foetida, is a triterpene glycoside, showing inhibitory role in breast cancer cells. However, the effects of ACT treatment on gastric cancer have little been known. Thus, the study is conducted to explore the in vitro and in vivo role of ACT...detailed

A transcriptomic analysis of black cohosh: Actein (cas 18642-44-9) alters cholesterol biosynthesis pathways and synergizes with simvastatin09/07/2019

Previous studies indicate that the herb black cohosh (Actaea racemosa L.) and the triterpene glycoside actein inhibit the growth of human breast cancer cells and activate stress-associated responses. This study assessed the transcriptomic effects of black cohosh and actein on rat liver tissue, u...detailed

Relevant articles and documents

Studies on the constituents of Cimicifuga species. XX. Absolute stereostructures of cimicifugoside and actein from Cimicifu simplex WORMSK

The absolute stereostructues of cimicifugoside (1) and actein (2) from Cimicifuga simplex were established by X-ray crystal analysis of 26(S)-O- methylcimicifugenin A (1cS) prepared from 1, negative CD curves of 26-O- methyl-3-keto-cimicifugenins (1dS, 1dR), comparative analysis of 1H- and 13C-NMR spectra of 1, 2 and their derivatives, and preparation of 2 from 1 by hydrogenation: 20(R), 23(R), 24(R), 25(S), 26 (R,S)-16β:23; 23:26; 24:25- triepoxy-12β-acetoxy-3β,26-dihydroxy-9,19-cyclolanost-7-ene 3-O-β-D- xylopyranoside for 1 and 20(R), 23(R), 24(R), 25(S), 26(R,S)-16β: 23; 23: 26; 24:25-triepoxy-12β-acetoxy-3β,26-dihydroxy-9,19-cyclolanostane 3-O-β- D-xylopyranoside for 2.