186449-17-2Relevant academic research and scientific papers
A unified total synthesis of the immunomodulators (-)-rapamycin and (-)-27-demethoxyrapamycin: Construction of the C(21-42) perimeters
Smith III, Amos B.,Condon, Stephen M.,McCauley, John A.,Leazer Jr., Johnnie L.,Leahy, James W.,Maleczka Jr., Robert E.
, p. 947 - 961 (2007/10/03)
A total synthesis of the potent, naturally occurring immunomodulators (-)-rapamycin (1) and (-)-27-demethoxyrapamycin (2) has been achieved via a unified, highly convergent synthetic strategy. Both targets were elaborated from common building blocks A-E,
