Cas 186450-84-0,(3E,5E,11E,13E)-(7R,8S,9S,15S,16R)-16-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8-hydroxy-15-methoxy-3,5,7,9,11-pentamethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one

186450-84-0

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Basic information

Product Name: (3E,5E,11E,13E)-(7R,8S,9S,15S,16R)-16-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8-hydroxy-15-methoxy-3,5,7,9,11-pentamethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one
Synonyms: (3E,5E,11E,13E)-(7R,8S,9S,15S,16R)-16-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8-hydroxy-15-methoxy-3,5,7,9,11-pentamethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one
CAS NO:186450-84-0
Molecular Formula:
Molecular Weight: 644.967
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: (3E,5E,11E,13E)-(7R,8S,9S,15S,16R)-16-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8-hydroxy-15-methoxy-3,5,7,9,11-pentamethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one(CAS DataBase Reference)
NIST Chemistry Reference: (3E,5E,11E,13E)-(7R,8S,9S,15S,16R)-16-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8-hydroxy-15-methoxy-3,5,7,9,11-pentamethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one(186450-84-0)
EPA Substance Registry System: (3E,5E,11E,13E)-(7R,8S,9S,15S,16R)-16-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8-hydroxy-15-methoxy-3,5,7,9,11-pentamethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one(186450-84-0)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 186450-84-0(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 186450-84-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,6,4,5 and 0 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 186450-84:
(8*1)+(7*8)+(6*6)+(5*4)+(4*5)+(3*0)+(2*8)+(1*4)=160
160 % 10 = 0
So 186450-84-0 is a valid CAS Registry Number.

186450-84-0Upstream product

186425-07-0 (2E,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-17-(tert-Butyl-diphenyl-silanyloxy)-7,15-dihydroxy-14-methoxy-2,4,6,8,10,16-hexamethyl-heptadeca-2,4,10,12-tetraenoic acid

186450-84-0Downstream Products

90965-58-5 (3E,5E,11E,13E)-(7R,8S,9S,15S,16R)-16-[(1S,2R,3S)-3-((2R,4R,5R,6R)-6-Ethyl-2,4-dihydroxy-5-methyl-tetrahydro-pyran-2-yl)-2-hydroxy-1-methyl-butyl]-8-hydroxy-15-methoxy-3,5,7,9,11-pentamethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one

186450-84-0Relevant academic research and scientific papers

Total synthesis of 16-membered tetraene macrolide hygrolidin

Makino, Kazuishi,Nakajima, Noriyuki,Hashimoto, Shun-Ichi,Yonemitsu, Osamu

, p. 9077 - 9080 (2007/10/03)

The first total synthesis of 16-membered tetraene macrolide antibiotic hygrolidin, a potent and relatively specific inhibitor of the vacuolar ATPases, has been achieved, incorporating macrolactonization by the modified Yamaguchi method and fragment assemb

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