186489-69-0

Upstream product

• 141505-96-6 (2R,4R,5R)-1-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-5-hydroxy-2,4,6-trimethyl-hept-6-ene-1,3-dione 
• 77-76-9 2,2-dimethoxy-propane 
• 186489-68-9 (4R)-4-benzyl-3-((2R,3S,4S,5R)-3,5-dihydroxy-2,4,6-trimethyl-1-oxo-6-heptenyl)-2-oxazolidinone 
• 101712-01-0 (R)-1-((R)-4-benzyl-2-oxooxazolidin-3-yl)-2-methylpentane-1,3-dione 

Downstream Products

• 186489-70-3 (4R)-4-benzyl-3-{(2R)-2-[(4S,5R,6S)-6-((1S)-2-hydroxy-1-methylethyl)-2,2,5-trimethyl-m-dioxan-4-yl]propionyl}-2-oxazolidinone 

Relevant academic research and scientific papers

General strategies toward the syntheses of macrolide antibiotics. The total syntheses of 6-deoxyerythronolide B and oleandolide

The asymmetric syntheses of 6-deoxyerythronolide B (1) and oleandolide (2) have been achieved, each in 18 linear steps. These syntheses demonstrate the utility of chiral β-keto imide building block 3 as a versatile building block for the aldol-based assemblage of polypropionate-derived natural products.