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Alisol B, a triterpenoid compound derived from the roots of the Alisma orientale plant, exhibits a range of pharmacological properties, such as anti-inflammatory, anti-cancer, anti-diabetic, and hepatoprotective effects. Its ability to inhibit cancer cell growth, reduce inflammation, and improve insulin sensitivity, along with its liver-protective qualities, positions Alisol B as a promising natural compound for various therapeutic applications.

18649-93-9

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Basic information
1. Product Name: Alisol B
2. Synonyms: ALISOL B;(23S,24R)-24,25-Epoxy-11b,23-dihydroxy-8a,9b,14b-dammar-13(17)-en-3-one;(8α,9β,14β,23S,24R)-11β,23-Dihydroxy-24,25-epoxy-5α-dammar-13(17)-en-3-one
3. CAS NO:18649-93-9
4. Molecular Formula: C₃₀H₄₈O₄
5. Molecular Weight: 444.65
6. EINECS: N/A
7. Product Categories: Triterpenoids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
8. Mol File: 18649-93-9.mol
Chemical Properties
1. Melting Point: 166-168 °C
2. Boiling Point: 575.1°Cat760mmHg
3. Flash Point: 179.1°C
4. Appearance: /
5. Density: 1.12g/cm³
6. Vapor Pressure: 1.27E-15mmHg at 25°C
7. Refractive Index: 1.553
8. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
9. Solubility: N/A
10. PKA: 14.35±0.20(Predicted)
11. CAS DataBase Reference: Alisol B(CAS DataBase Reference)
12. NIST Chemistry Reference: Alisol B(18649-93-9)
13. EPA Substance Registry System: Alisol B(18649-93-9)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 18649-93-9(Hazardous Substances Data)

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18649-93-9 Usage

Uses

Used in Pharmaceutical Industry:
Alisol B is used as an anti-inflammatory agent for its capacity to reduce inflammation, which can be beneficial in treating conditions characterized by excessive inflammation.
Alisol B is used as an anti-cancer agent for its ability to inhibit the growth of cancer cells, making it a potential therapeutic option for cancer treatment.
Alisol B is used as an anti-diabetic agent for its potential to improve insulin sensitivity, which can help manage blood sugar levels in diabetic individuals.
Alisol B is used as a hepatoprotective agent for its protective effects on the liver, offering a potential treatment for liver diseases caused by toxins or other damage.
Alisol B is also used in Drug Delivery Systems:
Innovative drug delivery systems are being developed to enhance the bioavailability and therapeutic outcomes of Alisol B, particularly for targeted cancer treatment, by employing various organic and metallic nanoparticles as carriers.

Check Digit Verification of cas no

The CAS Registry Mumber 18649-93-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,6,4 and 9 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 18649-93:
(7*1)+(6*8)+(5*6)+(4*4)+(3*9)+(2*9)+(1*3)=149
149 % 10 = 9
So 18649-93-9 is a valid CAS Registry Number.

InChI:InChI=1/C30H48O4/c1-17(15-21(32)25-27(4,5)34-25)18-9-13-29(7)19(18)16-20(31)24-28(6)12-11-23(33)26(2,3)22(28)10-14-30(24,29)8/h17,20-22,24-25,31-32H,9-16H2,1-8H3/t17-,20+,21?,22?,24+,25?,28+,29+,30+/m1/s1

18649-93-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name	Alisol B

1.2 Other means of identification

Product number	-
Other names	-

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18649-93-9 SDS

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18649-93-9Related news

A UFLC/MS/MS method for simultaneous quantitation of alisol A and Alisol B (cas 18649-93-9) 23-acetate from Alisma orientale (Sam.) Juz. in rat plasma07/14/2019

A sensitive and reliable ultra fast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method has been developed and validated for simultaneous quantitation of alisol A and alisol B 23-acetate from Alisma orientale (Sam.) Juz. in rat plasma using diazepam as an internal standard (IS). T...detailed

Antiproliferative activity of Alisol B (cas 18649-93-9) in MDA-MB-231 cells is mediated by apoptosis, dysregulation of mitochondrial functions, cell cycle arrest and generation of reactive oxygen species07/13/2019

Previous studies have demonstrated that Alisol B has inhibitory activity in cancer cells. However, the exact mechanism through which inhibition is achieved is still poorly understood. In the present study, the authors examined the effects of Alisol B in human breast cancer cells. Alisol B showed...detailed

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