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186495-49-8

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186495-49-8 Usage

Uses

Neuroprotection (NMDA receptor antagonist).

Check Digit Verification of cas no

The CAS Registry Mumber 186495-49-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,6,4,9 and 5 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 186495-49:
(8*1)+(7*8)+(6*6)+(5*4)+(4*9)+(3*5)+(2*4)+(1*9)=188
188 % 10 = 8
So 186495-49-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H17F2N/c1-19-9-8-16(12-4-2-6-14(17)10-12)13-5-3-7-15(18)11-13/h2-7,10-11,16,19H,8-9H2,1H3

186495-49-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,3-bis(3-fluorophenyl)-N-methylpropan-1-amine

1.2 Other means of identification

Product number -
Other names NPS 1506

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:186495-49-8 SDS

186495-49-8Upstream product

186495-49-8Downstream Products

186495-49-8Relevant academic research and scientific papers

Synthesis and brain regional distribution of [11C]NPS 1506 in mice and rat: An N-methyl-D-aspartate (NMDA) receptor antagonist

Fuchigami, Takeshi,Haradahira, Terushi,Arai, Takuya,Okauchi, Takashi,Maeda, Jun,Suzuki, Kazutoshi,Yamamoto, Fumihiko,Suhara, Tetsuya,Sasaki, Shigeki,Maeda, Minoru

, p. 1570 - 1573 (2003)

NPS 1506 [3-fluoro-γ-(3-fluorophenyl)-N-methylbenzenepropamine] is representative of a non-psychotomimetic class of N-methyl-D-aspartate (NMDA) receptor antagonists. [11C]NPS 1506 was prepared at high radiochemical purity (γ98%) with a specific activity of around 50 GBq/μmmol at the end of synthesis by methylation of the desmethyl precursor with [11C]methyl iodide in the presence of NaH. Biodistribution of [11C]NPS 1506 in mice and rat demonstrated that uptake into the brain was rapid and occurred at high levels. [11C]NPS 1506 showed no appreciable specific binding in rodent brains under in vivo conditions, possibly because of both a large non-specific bound fraction and low in vitro binding affinity for NMDA receptors.

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