186495-93-2 Usage
General Description
(-)-4,4-Bis(3-fluorophenyl)butan-2(S)-amine hydrochloride is a chemical compound that is a hydrochloride salt of an amine. The compound has a molecular formula of C16H20F2N.HCl and a molecular weight of 305.79 g/mol. It is a chiral compound with a specific stereochemistry, denoted by the (S)- designation in its name. The compound is a white to off-white crystalline solid that is sparingly soluble in water. It may have applications in pharmaceutical research and development, particularly in the synthesis of chiral molecules and drug discovery. As with any chemical compound, proper handling and safety precautions should be observed when working with (-)-4,4-Bis(3-fluorophenyl)butan-2(S)-amine hydrochloride.
Check Digit Verification of cas no
The CAS Registry Mumber 186495-93-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,6,4,9 and 5 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 186495-93:
(8*1)+(7*8)+(6*6)+(5*4)+(4*9)+(3*5)+(2*9)+(1*3)=192
192 % 10 = 2
So 186495-93-2 is a valid CAS Registry Number.
186495-93-2Relevant articles and documents
Chiral synthesis and pharmacological evaluation of NPS 1407: A potent, stereoselective NMDA receptor antagonist
Moe, Scott T.,Smith, Daryl L.,DelMar, Eric G.,Shimizu, Scot M.,Van Wagenen, Bradford C.,Balandrin, Manuel F.,Chien, Yongwei,Raszkiewicz, Joanna L.,Artman, Linda D.,White,Mueller, Alan L.
, p. 2411 - 2415 (2000)
The stereoselective synthesis and biological activity of NPS 1407 (4a), (S)-(-)-3-amino-1,1-bis(3-fluorophenyl)butane, a potent, stereoselective antagonist of the NMDA receptor, are described. The racemate (4) was found to be active at the NMDA receptor in an in vitro assay, prompting the synthesis of the individual stereoisomers. The S isomer (4a) was found to be 12 times more potent than the R isomer (4b). Compound 4a demonstrated in vivo pharmacological activity in neuroprotection and anti-convulsant assays. (C) 2000 Elsevier Science Ltd.
