186496-27-5Relevant academic research and scientific papers
Design and synthesis of N-(3,3-diphenylpropenyl)alkanamides as a novel class of high-affinity MT2-selective melatonin receptor ligands
Bedini, Annalida,Spadoni, Gilberto,Gatti, Giuseppe,Lucarini, Simone,Tarzia, Giorgio,Rivara, Silvia,Lorenzi, Simone,Lodola, Alessio,Mor, Marco,Lucini, Valeria,Pannacci, Marilou,Scaglione, Francesco
, p. 7393 - 7403 (2007/10/03)
A novel series of melatonin receptor ligands was discovered by opening the cyclic scaffolds of known classes of high affinity melatonin receptor antagonists, while retaining the pharmacophore elements postulated by previously described 3D-QSAR and recepto
Electrocyclic Aromatic Substitution by Nitrile Ylides to give 3H-2-Benzazepines: Substituent Effects and Mechanism
Groundwater, Paul W.,Sharp, John T.
, p. 7951 - 7964 (2007/10/02)
Benzonitrile 3,3-diarylallyl nitrile ylides (16), generated by the base-induced dehydrochlorination of imidoyl chlorides, cyclised by 1,7-ring closure to give 3H-2-benzazepines e.g. (19), in contrast to analogous diazo-compounds (1) which prefer 1,5-elect
